RT Journal Article
T1 Comparison of Interim PET Response to Second-Line Versus First-Line Treatment in Classic Hodgkin Lymphoma: Contribution to the Development of Response Criteria for Relapsed or Progressive Disease.
A1 Kluge, Regine
A1 Wittig, Tim
A1 Georgi, Thomas W
A1 Kurch, Lars
A1 Sabri, Osama
A1 Wallace, W Hamish
A1 Klekawka, Tomasz
A1 Fernández-Teijeiro, Ana
A1 Ceppi, Francesco
A1 Karlén, Jonas
A1 Pears, Jane
A1 Cepelová, Michaela
A1 Fosså, Alexander
A1 Beishuizen, Auke
A1 Hjalgrim, Lisa Lyngsie
A1 Körholz, Dieter
A1 Mauz-Körholz, Christine
A1 Hasenclever, Dirk
K1 Hodgkin lymphoma
K1 PET response criteria
K1 relapse
AB In first-line treatment of Hodgkin lymphoma (HL), Deauville scores 1-3 define complete metabolic remission. Interim 18F-FDG PET is also used for relapse-treatment adaptation; however, PET response criteria are not validated for relapse treatment. Methods: We performed a pairwise comparative analysis of early response to first- and second-line treatments in 127 patients with classic HL who experienced relapse. The patients participated in the prospective, multicenter EuroNet-PHL-C1 study. Residual uptake was measured retrospectively using the qPET method, a validated semiautomatic quantitative extension of the Deauville score. Empiric cumulative distribution functions of the qPET values were used to systematically analyze the response to first- and second-line treatments. Results: Individual patients responded variably to first- and second-line treatments. However, the empiric cumulative distribution functions of the qPET values from all patients were nearly superimposable. Conclusion: The findings support that first- and second-line treatments in HL do not require different response criteria.
YR 2020
FD 2020-08-06
LK http://hdl.handle.net/10668/16064
UL http://hdl.handle.net/10668/16064
LA en
DS RISalud
RD Apr 5, 2025