%0 Journal Article
%A Kluge, Regine
%A Wittig, Tim
%A Georgi, Thomas W
%A Kurch, Lars
%A Sabri, Osama
%A Wallace, W Hamish
%A Klekawka, Tomasz
%A Fernández-Teijeiro, Ana
%A Ceppi, Francesco
%A Karlén, Jonas
%A Pears, Jane
%A Cepelová, Michaela
%A Fosså, Alexander
%A Beishuizen, Auke
%A Hjalgrim, Lisa Lyngsie
%A Körholz, Dieter
%A Mauz-Körholz, Christine
%A Hasenclever, Dirk
%T Comparison of Interim PET Response to Second-Line Versus First-Line Treatment in Classic Hodgkin Lymphoma: Contribution to the Development of Response Criteria for Relapsed or Progressive Disease.
%D 2020
%U http://hdl.handle.net/10668/16064
%X In first-line treatment of Hodgkin lymphoma (HL), Deauville scores 1-3 define complete metabolic remission. Interim 18F-FDG PET is also used for relapse-treatment adaptation; however, PET response criteria are not validated for relapse treatment. Methods: We performed a pairwise comparative analysis of early response to first- and second-line treatments in 127 patients with classic HL who experienced relapse. The patients participated in the prospective, multicenter EuroNet-PHL-C1 study. Residual uptake was measured retrospectively using the qPET method, a validated semiautomatic quantitative extension of the Deauville score. Empiric cumulative distribution functions of the qPET values were used to systematically analyze the response to first- and second-line treatments. Results: Individual patients responded variably to first- and second-line treatments. However, the empiric cumulative distribution functions of the qPET values from all patients were nearly superimposable. Conclusion: The findings support that first- and second-line treatments in HL do not require different response criteria.
%K Hodgkin lymphoma
%K PET response criteria
%K relapse
%~