RT Journal Article
T1 Effectiveness of lanreotide autogel 120 mg at extended dosing intervals for acromegaly.
A1 Bernabéu, Ignacio
A1 Fajardo, Carmen
A1 Marazuela, Mónica
A1 Cordido, Fernando
A1 Venegas, Eva María
A1 de Pablos-Velasco, Pedro
A1 Maroto, Gonzalo Piedrola
A1 Olvera, María Pilar
A1 de Paz, Isabel Pavón
A1 Carvalho, Davide
A1 Romero, Carme
A1 De la Cruz, Guillermo
A1 Escolá, Cristina Álvarez
K1 Acromegaly
K1 Growth hormone
K1 Insulin-like growth factor 1
K1 Lanreotide
K1 Somatostatin
AB Recent data indicate that extended dosing intervals (EDIs) with lanreotide autogel 120 mg are effective and well-received among patients with acromegaly who have achieved biochemical control with monthly injections of long-acting somatostatin analogues (SSAs). We further evaluated the effectiveness of lanreotide autogel 120 mg delivered at EDIs (>4 weeks) in routine clinical practice. Cross-sectional, multicentre, observational study conducted to determine the effectiveness-measured by control of serum insulin-like growth factor 1 (IGF-1)-of lanreotide autogel 120 mg at dosing intervals >4 weeks for ≥6 months in selected patients with acromegaly treated in routine clinical practice (NCT02807233). Secondary assessments included control of growth hormone (GH) levels, treatment adherence, patient satisfaction, and quality of life (QoL) using validated questionnaires (EQ-5D, AcroQoL, and TSQM-9). Patients who received radiotherapy within the last 6 months were excluded. Among 109 patients evaluated, mean (SD) age was 59.1 (13.2) years. IGF-1 values were normal (mean [SD]: 175.0 [74.5], 95% CI: 160.8 -189.1) in 91.7% of cases and normal in 91.4% of patients without previous radiotherapy treatment (n = 81). GH levels were ≤2.5 and ≤1 ng/mL, respectively, in 80.6% and 58.3%. Most patients were treated either every 5-6 (57.8%) or 7-8 weeks (38.5%), with 2.8% treated greater than every 8 weeks. The mean AcroQoL score was 63.0 (20.1). The mean global treatment satisfaction score (TSQM-9) was 75.1 (16.6). Treatment adherence (defined as no missed injections) was 94.5%. Lanreotide autogel 120 mg at intervals of >4 weeks provided IGF-1 control in more than 90% of patients with acromegaly. Treatment satisfaction and adherence were good. These findings support use of extended dosing intervals in patients who have achieved good biochemical control with long-acting SSAs.
YR 2020
FD 2020-07-28
LK http://hdl.handle.net/10668/16023
UL http://hdl.handle.net/10668/16023
LA en
DS RISalud
RD Apr 14, 2025