RT Journal Article
T1 Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe.
A1 Forns, Joan
A1 Sunyer, Jordi
A1 Garcia-Esteban, Raquel
A1 Porta, Daniela
A1 Ghassabian, Akhgar
A1 Giorgis-Allemand, Lise
A1 Gong, Tong
A1 Gehring, Ulrike
A1 Sørensen, Mette
A1 Standl, Marie
A1 Sugiri, Dorothee
A1 Almqvist, Catarina
A1 Andiarena, Ainara
A1 Badaloní, Chiara
A1 Beelen, Rob
A1 Berdel, Dietrich
A1 Cesaroni, Giulia
A1 Charles, Marie-Aline
A1 Eriksen, Kirsten Thorup
A1 Estarlich, Marisa
A1 Fernandez, Mariana F
A1 Forhan, Anne
A1 Jaddoe, Vincent W V
A1 Korek, Michal
A1 Lichtenstein, Paul
A1 Lertxundi, Aitana
A1 Lopez-Espinosa, Maria-Jose
A1 Markevych, Iana
A1 de Nazelle, Audrey
A1 Raaschou-Nielsen, Ole
A1 Nieuwenhuijsen, Mark
A1 Pérez-Lobato, Rocío
A1 Philippat, Claire
A1 Slama, Rémy
A1 Tiesler, Carla M T
A1 Verhulst, Frank C
A1 von Berg, Andrea
A1 Vrijkotte, Tanja
A1 Nybo Andersen, Anne-Marie
A1 Heude, Barbara
A1 Krämer, Ursula
A1 Heinrich, Joachim
A1 Tiemeier, Henning
A1 Forastiere, Francesco
A1 Pershagen, Göran
A1 Brunekreef, Bert
A1 Guxens, Mònica
K1 Attention deficit disorder with hyperactivity
K1 Child development
K1 Environmental pollution
K1 Longitudinal studies
K1 Meta-analysis
K1 Nitrogen oxides
K1 Particulate matter
K1 Prospective studies
AB Exposure to air pollution during pregnancy may increase attention-deficit/hyperactivity disorder (ADHD) symptoms in children, but findings have been inconsistent. We aimed to study this association in a collaborative study of eight European population-based birth/child cohorts, including 29,127 mother-child pairs. Air pollution concentrations (nitrogen dioxide [NO2] and particulate matter [PM]) were estimated at the birth address by land-use regression models based on monitoring campaigns performed between 2008 and 2011. We extrapolated concentrations back in time to exact pregnancy periods. Teachers or parents assessed ADHD symptoms at 3-10 years of age. We classified children as having ADHD symptoms within the borderline/clinical range and within the clinical range using validated cutoffs. We combined all adjusted area-specific effect estimates using random-effects meta-analysis and multiple imputations and applied inverse probability-weighting methods to correct for loss to follow-up. We classified a total of 2,801 children as having ADHD symptoms within the borderline/clinical range, and 1,590 within the clinical range. Exposure to air pollution during pregnancy was not associated with a higher odds of ADHD symptoms within the borderline/clinical range (e.g., adjusted odds ratio [OR] for ADHD symptoms of 0.95, 95% confidence interval [CI] = 0.89, 1.01 per 10 µg/m increase in NO2 and 0.98, 95% CI = 0.80, 1.19 per 5 µg/m increase in PM2.5). We observed similar associations for ADHD within the clinical range. There was no evidence for an increase in risk of ADHD symptoms with increasing prenatal air pollution levels in children aged 3-10 years. See video abstract at, http://links.lww.com/EDE/B379.
YR 2018
FD 2018-05-30
LK http://hdl.handle.net/10668/12616
UL http://hdl.handle.net/10668/12616
LA en
NO Forns J, Sunyer J, Garcia-Esteban R, Porta D, Ghassabian A, Giorgis-Allemand L, et al. Air Pollution Exposure During Pregnancy and Symptoms of Attention Deficit and Hyperactivity Disorder in Children in Europe. Epidemiology. 2018 Sep;29(5):618-626.
DS RISalud
RD Jul 6, 2025