RT Journal Article T1 Brain Structural and Functional Changes in Cognitive Impairment Due to Alzheimer's Disease. A1 Avila-Villanueva, Marina A1 Marcos Dolado, Alberto A1 Gomez-Ramirez, Jaime A1 Fernandez-Blazquez, Miguel K1 Cognitive impairment (CI) K1 Early markers K1 Functional changes K1 Reversion K1 Structural changes AB Cognitive neuropsychology seeks a potential alignment between structural and functional brain features to explain physiological or pathological processes, such as Alzheimer's disease (AD). Several structural and functional brain changes occurring during the disease, including cognitive impairment, are found at the end of the patient's life, but we need to know more about what happens before its onset. In order to do that, we need earlier biomarkers at preclinical stages, defined by those biomarkers, to prevent the cognitive impairment. In this minireview, we have tried to describe the structural and functional changes found at different stages during AD, focusing on those features taking place before clinical diagnosis. PB Frontiers Research Foundation SN 1664-1078 YR 2022 FD 2022-05-10 LK http://hdl.handle.net/10668/20727 UL http://hdl.handle.net/10668/20727 LA en NO Ávila-Villanueva M, Marcos Dolado A, Gómez-Ramírez J, Fernández-Blázquez M. Brain Structural and Functional Changes in Cognitive Impairment Due to Alzheimer's Disease. Front Psychol. 2022 Jun 21;13:886619 DS RISalud RD Apr 18, 2025