RT Journal Article T1 Comparison of dedicated BIOSS bifurcation stents with regular drug-eluting stents for coronary artery bifurcated lesions: Pooled analysis from two randomized studies. A1 Gil, Robert J A1 Bil, Jacek A1 Kern, Adam A1 Iñigo Garcia, Luis A A1 Formuszewicz, Radosław A1 Dobrzycki, Sławomir A1 Vassilev, Dobrin A1 Segiet, Agnieszka K1 coronary bifurcation K1 diabetes mellitus K1 drug eluting stent K1 left main K1 proximal optimization technique AB Coronary bifurcation treatment poses a therapeutic challenge. The aim of this study was to analyze pooled data of two randomized clinical trials, POLBOS I and POLBOS II, to compare 1-year follow-up results and identify possible prognostic factors. In POLBOS trials dedicated bifurcation BiOSS® stents were compared with regular drug eluting stents (rDES) in patients with stable coronary artery disease or non ST-segment elevation acute coronary syndrome (POLBOS I: paclitaxel eluting BiOSS® Expert vs. rDES; POLBOS II: sirolimus eluting BiOSS® LIM vs. rDES). Provisional T-stenting was the default strategy. Angiographic control was performed at 12 months. The primary endpoint was major adverse cardiovascular events (MACE) rate defined as the rate of cardiac death, myocardial infarction (MI) or target lesion revascularization (TLR). 445 patients, with 222 patients in the BiOSS group and 223 patients in the rDES group, were analyzed. In 26.7% cases procedures were performed within distal left main, and true bifurca-tions which accounted for 81.6% of treated lesions. At 12 months the whole population exhibited no statistical differences in terms of MACE, TLR, MI or cardiac death between rDES and BiOSS groups. In multivariate analysis odds for MACE decreased with female sex (OR 0.433, 95% CI 0.178-0.942, p = 0.047) and with proximal optimization technique use (OR 0.208, 95% CI 0.097-0.419, p Pooled data showed no significant difference between MACE and TLR rates for BiOSS® group vs. rDES group. YR 2017 FD 2017-08-25 LK https://hdl.handle.net/10668/26757 UL https://hdl.handle.net/10668/26757 LA en DS RISalud RD Apr 17, 2025