TY - JOUR AU - Villanueva-Paz, Marina AU - Morán, Laura AU - López-Alcántara, Nuria AU - Freixo, Cristiana AU - Andrade, Raúl J. AU - Lucena, M Isabel AU - Cubero, Francisco Javier PY - 2021 DO - 10.3390/antiox10030390 UR - http://hdl.handle.net/10668/3663 T2 - Antioxidants AB - Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an uncommon drug adverse reaction that can develop to conditions spanning from asymptomatic liver laboratory abnormalities to acute liver failure (ALF) and death. The... LA - en PB - MDPI KW - DILI KW - Oxidative stress KW - Risk factors KW - Biomarkers KW - Mechanisms KW - Estrés oxidativo KW - Factores de riesgo KW - Biomarcadores KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Glutathione Peroxidase KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Catalase KW - Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Multiprotein Complexes::Inflammasomes KW - Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Laboratories KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Oligopeptides::Glutathione KW - Medical Subject Headings::Anatomy::Cells::Epithelial Cells::Hepatocytes KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Superoxide Dismutase KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers KW - Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity KW - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Histocompatibility Antigens::HLA Antigens KW - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Endoplasmic Reticulum KW - Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Hepatic Insufficiency::Liver Failure::Liver Failure, Acute KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Acid Anhydride Hydrolases::GTP Phosphohydrolases::GTP-Binding Proteins KW - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Noxae::Oxidants TI - Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice TY - review article ER -