RT Journal Article
T1 Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model.
A1 Alvarez-Laderas, Isabel
A1 Ramos, Teresa L
A1 Medrano, Mayte
A1 Caracuel-García, Rocío
A1 Barbado, María Victoria
A1 Sánchez-Hidalgo, Marina
A1 Zamora, Rosario
A1 Alarcón-de-la-Lastra, Catalina
A1 Hidalgo, Francisco J
A1 Piruat, José Ignacio
A1 Caballero-Velázquez, Teresa
A1 Pérez-Simón, José Antonio
K1 Graft-versus-host disease
K1 Mouse model
K1 Polyphenolic extract
K1 Virgin olive oil
AB Polyphenols are a group of chemical substances found in plants, with immunomodulatory, antiproliferative, and anti-inflammatory properties that might be useful in the prophylaxis and treatment of graft-versus-host disease (GVHD). Polyphenolic extract (PE) obtained from extra virgin olive oil (EVOO) decreased the activation and proliferation of activated T cells. In addition, a decreased production of proinflammatory cytokines was observed upon exposure to PE. Western blot assays showed a marked inhibition of Akt phosphorylation and nuclear translocation of NF-κB in activated T cells. In a murine model of acute GVHD, we observed that mice that received a diet supplemented in PE (600 ppm) presented a higher survival rate and lower risk of developing GVHD when compared with the group that received a control diet. Histopathologic examination showed a significantly lower gut involvement in mice receiving PE, with a decrease in proinflammatory cytokines (IL-2, IL-17, and TNF-α) in serum and the reestablishment of butyrate concentration in the gut. In conclusion, PE obtained from EVOO exerted a potent immunomodulatory effect, reducing the activation and proliferation of activated T cells and the production of proinflammatory cytokines. In a murine model of acute GVHD, a PE-supplemented diet reduced the incidence and severity of the disease and increased survival after transplantation.
YR 2019
FD 2019-11-19
LK http://hdl.handle.net/10668/14733
UL http://hdl.handle.net/10668/14733
LA en
DS RISalud
RD Apr 17, 2025