%0 Journal Article
%A Alvarez-Laderas, Isabel
%A Ramos, Teresa L
%A Medrano, Mayte
%A Caracuel-García, Rocío
%A Barbado, María Victoria
%A Sánchez-Hidalgo, Marina
%A Zamora, Rosario
%A Alarcón-de-la-Lastra, Catalina
%A Hidalgo, Francisco J
%A Piruat, José Ignacio
%A Caballero-Velázquez, Teresa
%A Pérez-Simón, José Antonio
%T Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model.
%D 2019
%U http://hdl.handle.net/10668/14733
%X Polyphenols are a group of chemical substances found in plants, with immunomodulatory, antiproliferative, and anti-inflammatory properties that might be useful in the prophylaxis and treatment of graft-versus-host disease (GVHD). Polyphenolic extract (PE) obtained from extra virgin olive oil (EVOO) decreased the activation and proliferation of activated T cells. In addition, a decreased production of proinflammatory cytokines was observed upon exposure to PE. Western blot assays showed a marked inhibition of Akt phosphorylation and nuclear translocation of NF-κB in activated T cells. In a murine model of acute GVHD, we observed that mice that received a diet supplemented in PE (600 ppm) presented a higher survival rate and lower risk of developing GVHD when compared with the group that received a control diet. Histopathologic examination showed a significantly lower gut involvement in mice receiving PE, with a decrease in proinflammatory cytokines (IL-2, IL-17, and TNF-α) in serum and the reestablishment of butyrate concentration in the gut. In conclusion, PE obtained from EVOO exerted a potent immunomodulatory effect, reducing the activation and proliferation of activated T cells and the production of proinflammatory cytokines. In a murine model of acute GVHD, a PE-supplemented diet reduced the incidence and severity of the disease and increased survival after transplantation.
%K Graft-versus-host disease
%K Mouse model
%K Polyphenolic extract
%K Virgin olive oil
%~