TY  - JOUR
AU  - Al Mahmud, Md Rasel
AU  - Ishii, Kenichiro
AU  - Bernal-Lozano, Cristina
AU  - Delgado-Sainz, Irene
AU  - Toi, Masakazu
AU  - Akamatsu, Shusuke
AU  - Fukumoto, Manabu
AU  - Watanabe, Masatoshi
AU  - Takeda, Shunichi
AU  - Cortés-Ledesma, Felipe
AU  - Sasanuma, Hiroyuki
PY  - 2020
DO  - 10.1111/gtc.12770
UR  - http://hdl.handle.net/10668/15356
T2  - Genes to cells : devoted to molecular & cellular mechanisms
AB  - Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating the transcription of target genes. TOP2 resolves the entanglement of genomic DNA by transiently generating double-strand...
LA  - en
KW  - DNA double-strand break
KW  - TDP2
KW  - androgen
KW  - atypical epithelial hyperplasia
KW  - prostatic intraepithelial neoplasia
KW  - topoisomerase 2
KW  - Androgens
KW  - Animals
KW  - Cell Line
KW  - Cell Proliferation
KW  - Chromosome Breakage
KW  - DNA Breaks, Double-Stranded
KW  - DNA End-Joining Repair
KW  - DNA-Binding Proteins
KW  - Epithelial Cells
KW  - G1 Phase Cell Cycle Checkpoints
KW  - Genomic Instability
KW  - Histones
KW  - Humans
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Phosphoric Diester Hydrolases
KW  - Prostate
KW  - Prostatic Neoplasms
KW  - RNA, Small Interfering
KW  - Receptors, Androgen
TI  - TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands.
TY  - research article
VL  - 25
ER  -