RT Generic
T1 Resistant/Refractory Hypertension and Sleep Apnoea: Current Knowledge and Future Challenges.
A1 Oscullo, Grace
A1 Torres, Gerard
A1 Campos-Rodriguez, Francisco
A1 Posadas, Tomas
A1 Reina-Gonzalez, Angela
A1 Sapiña-Beltran, Esther
A1 Barbe, Ferran
A1 Martinez-Garcia, Miguel Angel
K1 Continuous positive airway pressure
K1 Obstructive sleep apnoea
K1 Refractory hypertension
K1 Resistant hypertension
AB Hypertension is one of the most frequent cardiovascular risk factors. The population of hypertensive patients includes some phenotypes whose blood pressure levels are particularly difficult to control, thus putting them at greater cardiovascular risk. This is especially true of so-called resistant hypertension (RH) and refractory hypertension (RfH). Recent findings suggest that the former may be due to an alteration in the renin-angiotensin-aldosterone axis, while the latter seems to be more closely related to sympathetic hyper-activation. Both these pathophysiological mechanisms are also activated in patients with obstructive sleep apnoea (OSA). It is not surprising, therefore, that the prevalence of OSA in RH and RfH patients is very high (as reflected in several studies) and that treatment with continuous positive airway pressure (CPAP) manages to reduce blood pressure levels in a clinically significant way in both these groups of hypertensive patients. It is therefore necessary to incorporate into the multidimensional treatment of patients with RH and RfH (changes in lifestyle, control of obesity and drug treatment) a study of the possible existence of OSA, as this is a potentially treatable disease. There are many questions that remain to be answered, especially regarding the ideal combination of treatment in patients with RH/RfH and OSA (drugs, renal denervation, CPAP treatment) and patients' varying response to CPAP treatment.
PB MDPI AG
SN 2077-0383
YR 2019
FD 2019-11-05
LK https://hdl.handle.net/10668/27163
UL https://hdl.handle.net/10668/27163
LA en
NO Oscullo G, Torres G, Campos-Rodriguez F, Posadas T, Reina-González A, Sapiña-Beltrán E, et al. Resistant/Refractory Hypertension and Sleep Apnoea: Current Knowledge and Future Challenges. J Clin Med. 2019 Nov 5; 8(11) : 1872.
DS RISalud
RD Apr 5, 2025