RT Journal Article
T1 Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles.
A1 Nicoletti, Paola
A1 Aithal, Guruprasad P
A1 Chamberlain, Thomas C
A1 Coulthard, Sally
A1 Alshabeeb, Mohammad
A1 Grove, Jane I
A1 Andrade, Raul J
A1 Bjornsson, Einar
A1 Dillon, John F
A1 Hallberg, Par
A1 Lucena, M Isabel
A1 Maitland-van der Zee, Anke H
A1 Martin, Jennifer H
A1 Molokhia, Mariam
A1 Pirmohamed, Munir
A1 Wadelius, Mia
A1 Shen, Yufeng
A1 Nelson, Matthew R
A1 Daly, Ann K
K1 Anti-bacterial agents
K1 Liver injury
K1 Floxacillin
K1 HLA-B antigens
AB Some patients prescribed flucloxacillin (~ 0.01%) develop drug-induced liver injury (DILI). HLA-B*57:01 is an established genetic risk factor for flucloxacillin DILI. To consolidate this finding, identify additional genetic factors, and assess relevance of risk factors for flucloxacillin DILI in relation to DILI due to other penicillins, we performed a genomewide association study involving 197 flucloxacillin DILI cases and 6,835 controls. We imputed single-nucleotide polymorphism and human leukocyte antigen (HLA) genotypes. HLA-B*57:01 was the major risk factor (allelic odds ratio (OR) = 36.62; P = 2.67 × 10-97 ). HLA-B*57:03 also showed an association (OR = 79.21; P = 1.2 × 10-6 ). Within the HLA-B protein sequence, imputation showed valine97 , common to HLA-B*57:01 and HLA-B*57:03, had the largest effect (OR = 38.1; P = 9.7 × 10-97 ). We found no HLA-B*57 association with DILI due to other isoxazolyl penicillins (n = 6) or amoxicillin (n = 15) and no significant non-HLA signals for any penicillin-related DILI.
PB Wiley
YR 2018
FD 2018-12-13
LK http://hdl.handle.net/10668/13436
UL http://hdl.handle.net/10668/13436
LA en
NO Nicoletti P, Aithal GP, Chamberlain TC, Coulthard S, Alshabeeb M, Grove JI, et al. Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles. Clin Pharmacol Ther. 2019 Jul;106(1):245-253
DS RISalud
RD Apr 6, 2025