RT Journal Article
T1 Phylodynamic and Phylogeographic Profiles of Subtype B HIV-1 Epidemics in South Spain
A1 Perez-Parra, Santiago
A1 Chueca, Natalia
A1 Alvarez, Marta
A1 Pasquau, Juan
A1 Omar, Mohamed
A1 Collado, Antonio
A1 Vinuesa, David
A1 Lozano, Ana B.
A1 Yebra, Gonzalo
A1 Garcia, Federico
K1 Molecular epidemiology
K1 Drug-resistance
K1 Transmission dynamics
K1 Population-dynamics
K1 Antiretroviral therapy
K1 Infected individuals
K1 Northwest spain
K1 Basque country
K1 Prevalence
K1 Evolution
AB BackgroundSince 1982, HIV-1 epidemics have evolved to different scenarios in terms of transmission routes, subtype distribution and characteristics of transmission clusters. We investigated the evolutionary history of HIV-1 subtype B in south Spain.Patients & MethodsWe studied all newly diagnosed HIV-1 subtype B patients in East Andalusia during the 2005-2012 period. For the analysis, we used the reverse transcriptase and protease sequences from baseline resistance, and the Trugene (R) HIV Genotyping kit (Siemens, Barcelona, Spain). Subtyping was done with REGA v3.0. The maximum likelihood trees constructed with RAxML were used to study HIV-1 clustering. Phylogeographic and phylodynamic profiles were studied by Bayesian inference methods with BEAST v1.7.5 and SPREAD v1.0.6.ResultsOf the 493 patients infected with HIV-1 subtype B, 234 grouped into 55 clusters, most of which were small (44 clusters = 5 patients, and most (82%, 109/133) were men who have sex with men (MSM) grouped into 8 clusters. The association with clusters was more frequent in Spanish (p = 0.02) men (p
PB Public library science
SN 1932-6203
YR 2016
FD 2016-12-21
LK http://hdl.handle.net/10668/19169
UL http://hdl.handle.net/10668/19169
LA en
DS RISalud
RD May 9, 2025