RT Journal Article
T1 A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease.
A1 Varela-Lopez, Alfonso
A1 Bullon, Pedro
A1 Ramirez-Tortosa, Cesar L
A1 Navarro-Hortal, Maria D
A1 Robles-Almazan, Maria
A1 Bullon, Beatriz
A1 Cordero, Mario D
A1 Battino, Maurizio
A1 Quiles, Jose L
K1 NASH
K1 atherogenic
K1 atherosclerosis
K1 non-alcoholic fatty liver disease
K1 periodontal diseases
K1 periodontitis
K1 rabbits
AB Increasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard diet or a diet rich in saturated fat (3% lard w/w) and cholesterol (1.3% w/w) (HFD) for 40 days. Half of the rabbits on each diet were treated 2 days per week with intragingival injections of LPS from Porphyromonas gingivalis. Morphometric analyses revealed that LPS induced higher alveolar bone loss (ABL) around the first premolar in animals receiving standard diets, which was exacerbated by the HFD diet. A higher score of acinar inflammation in the liver and higher blood levels of triglycerides and phospholipids were found in HFD-fed rabbits receiving LPS. These results suggest that certain dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can contribute to dyslipidemia and promote NAFLD progression, but only under certain conditions.
PB MDPI AG
YR 2020
FD 2020-05-14
LK http://hdl.handle.net/10668/15585
UL http://hdl.handle.net/10668/15585
LA en
NO Varela-López A, Bullón P, Ramírez-Tortosa CL, Navarro-Hortal MD, Robles-Almazán M, Bullón B, et al. A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of Periodontal Disease. Nutrients. 2020 May 14;12(5):1405.
DS RISalud
RD Mar 12, 2025