RT Journal Article
T1 Cortical Oxygenation during a Motor Task to Evaluate Recovery in Subacute Stroke Patients: A Study with Near-Infrared Spectroscopy.
A1 Lamberti, Nicola
A1 Manfredini, Fabio
A1 Nardi, Francesca
A1 Baroni, Andrea
A1 Piva, Giovanni
A1 Crepaldi, Anna
A1 Basaglia, Nino
A1 Casetta, Ilaria
A1 Straudi, Sofia
K1 Cortical activity
K1 Exercise testing
K1 Exercise therapy
K1 Motor task
K1 Near-infrared spectroscopy
K1 Rehabilitation
K1 Stroke
AB In subacute stroke patients we studied cortical oxygenation changes by near-infrared spectroscopy (NIRS) during a motor task performed with the hemiparetic arm (15 s of reaching and grasping, 45 s of rest, repeated 6 times). Twenty-three subjects were included at baseline, compared with six healthy subjects, and restudied after 6 weeks of rehabilitation. Motor/premotor cortical changes in oxyhemoglobin detected by NIRS were quantified as the area under the curve (AUC) for the total cortex (TOT-AUC) and for both affected (AFF-AUC) and unaffected hemispheres (UN-AUC). The ratio between AUC and the number of task repetitions performed identified the cortical metabolic cost (CMC) or the oxygenation increase for a single movement. Fugl−Meyer assessment of the upper extremity (FMA-UE) was also performed. At baseline, both total and hemispheric CMC were significantly higher in stroke patients than in healthy subjects and inversely correlated with FMA-UE. After rehabilitation, changes in total-CMC and unaffected-CMC, but not Affected-CMC, were inversely correlated with variations in the FMA-UE score. A value > 5000 a.u. for the ratio baseline TOT-CMC/days since stroke was associated with not reaching the clinically important difference for FMA-UE after rehabilitation. In subacute stroke the CMC, a biomarker assessed by NIRS during a motor task with the hemiparetic arm, may describe cortical time/treatment reorganization and favor patient selection for rehabilitation.
PB MDPI
SN 2035-8385
YR 2022
FD 2022-03-21
LK http://hdl.handle.net/10668/21446
UL http://hdl.handle.net/10668/21446
LA en
NO Lamberti N, Manfredini F, Nardi F, Baroni A, Piva G, Crepaldi A, et al. Cortical Oxygenation during a Motor Task to Evaluate Recovery in Subacute Stroke Patients: A Study with Near-Infrared Spectroscopy. Neurol Int. 2022 Mar 23;14(2):322-335
DS RISalud
RD Aug 24, 2025