RT Journal Article
T1 Linking of psoriasis with osteopenia and osteoporosis: A cross-sectional study.
A1 Martinez-Lopez, Antonio
A1 Blasco-Morente, Gonzalo
A1 Giron-Prieto, Maria Sierra
A1 Arrabal-Polo, Miguel Angel
A1 Luque-Valenzuela, Maria
A1 Luna-Del Castillo, Juan de Dios
A1 Tercedor-Sanchez, Jesus
A1 Arias-Santiago, Salvador
K1 Body mass index
K1 bone mineral density
K1 osteopenia
K1 osteoporosis
K1 psoriasis
K1 vitamin-D
AB Psoriasis is a multisystem disease which has been related to vitamin-D deficiency through chronic inflammation. This psoriasis-related inflammatory state and vitamin-D deficiency may induce bone mineral density loss. The purpose of this study is to assess the relationship of psoriasis with bone mineral density, by comparing psoriatic patients with healthy controls and patients with osteopenia/osteoporosis. A total of 185 subjects were studied; 58 psoriatic patients who had not been under systemic or biological treatment were included. Age, gender, body mass index, phosphocalcic metabolic parameters and hip and lumbar (L4) bone mineral density data were collected. These variables were compared with those collected in 61 healthy controls and 67 patients with osteopenia/osteoporosis. Psoriatic patients showed worse hip and lumbar spine bone mineral density levels than healthy controls (P = 0.001) and better levels than osteoporotic patients (P  The main limitations are those of cross-sectional studies, such as a lack of follow up period, and a male predominance in the psoriatic group, which is corrected employing a multivariate analysis with an adjusted model for confounding factors. Bone mineral density levels in psoriatic patients are situated halfway between healthy controls and patients with osteopenia/osteoporosis. In addition, the higher body mass index in patients with psoriasis appears to confer a protective effect against further development of lower bone mineral density.
YR 2019
FD 2019
LK http://hdl.handle.net/10668/12959
UL http://hdl.handle.net/10668/12959
LA en
DS RISalud
RD May 9, 2025