RT Journal Article
T1 Recent advances in understanding and managing secondary hyperparathyroidism in chronic kidney disease.
A1 Rodríguez-Ortiz, María E
A1 Rodríguez, Mariano
K1 Chronic kidney disease-mineral and bone disorder
K1 caSR
K1 calcimimetics
K1 calcium
K1 chronic kidney disease
K1 etelcalcetide
K1 parathyroid
K1 parathyroidectomy
K1 secondary hyperparathyroidism
AB Secondary hyperparathyroidism is a complex pathology that develops as chronic kidney disease progresses. The retention of phosphorus and the reductions in calcium and vitamin D levels stimulate the synthesis and secretion of parathyroid hormone as well as the proliferation rate of parathyroid cells. Parathyroid growth is initially diffuse but it becomes nodular as the disease progresses, making the gland less susceptible to be inhibited. Although the mechanisms underlying the pathophysiology of secondary hyperparathyroidism are well known, new evidence has shed light on unknown aspects of the deregulation of parathyroid function. Secondary hyperparathyroidism is an important feature of chronic kidney disease-mineral and bone disorder and plays an important role in the development of bone disease and vascular calcification. Thus, part of the management of chronic kidney disease relies on maintaining acceptable levels of mineral metabolism parameters in an attempt to slow down or prevent the development of secondary hyperparathyroidism. Here, we will also review the latest evidence regarding several aspects of the clinical and surgical management of secondary hyperparathyroidism.
YR 2020
FD 2020-09-01
LK https://hdl.handle.net/10668/25604
UL https://hdl.handle.net/10668/25604
LA en
DS RISalud
RD Apr 9, 2025