RT Journal Article
T1 Immunometabolism Modulation in Therapy.
A1 Monferrer, Ezequiel
A1 Sanegre, Sabina
A1 Vieco-Martí, Isaac
A1 López-Carrasco, Amparo
A1 Fariñas, Fernando
A1 Villatoro, Antonio
A1 Abanades, Sergio
A1 Mañes, Santos
A1 de la Cruz-Merino, Luis
A1 Noguera, Rosa
A1 Álvaro Naranjo, Tomás
K1 immunometabolites
K1 metabolic reprogramming
K1 oncometabolites
K1 regulatory balance
AB The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importance on immune system cells. Enhanced understanding of the molecular bases that give rise to alterations of pathways related to tumor development can open up new therapeutic intervention opportunities, such as metabolic regulation applied to immunotherapy. This review outlines the role of various oncometabolites and immunometabolites, such as TCA intermediates, in shaping pro/anti-inflammatory activity of immune cells such as MDSCs, T lymphocytes, TAMs and DCs in cancer. We also discuss the extraordinary plasticity of the immune response and its implication in immunotherapy efficacy, and highlight different therapeutic intervention possibilities based on controlling the balanced systems of specific metabolites with antagonistic functions.
SN 2227-9059
YR 2021
FD 2021-07-09
LK https://hdl.handle.net/10668/27701
UL https://hdl.handle.net/10668/27701
LA en
DS RISalud
RD Apr 8, 2025