RT Journal Article
T1 Permanent postoperative hypoparathyroidism: an analysis of prevalence and predictive factors for adequacy of control in a cohort of 260 patients.
A1 Díez, Juan J
A1 Anda, Emma
A1 Sastre, Julia
A1 Pérez Corral, Begoña
A1 Álvarez-Escolá, Cristina
A1 Manjón, Laura
A1 Paja, Miguel
A1 Sambo, Marcel
A1 Santiago Fernández, Piedad
A1 Blanco Carrera, Concepción
A1 Galofré, Juan C
A1 Navarro, Elena
A1 Zafón, Carles
A1 Sanz, Eva
A1 Oleaga, Amelia
A1 Bandrés, Orosia
A1 Donnay, Sergio
A1 Megía, Ana
A1 Picallo, María
A1 Sánchez Ragnarsson, Cecilia
A1 Baena-Nieto, Gloria
A1 Fernández-García, José Carlos
A1 Lecumberri, Beatriz
A1 Sahún de la Vega, Manel
A1 Romero-Lluch, Ana R
A1 Iglesias, Pedro
K1 Permanent hypoparathyroidism
K1 adequacy of control
K1 parathyroid hormone (PTH)
K1 thyroidectomy
AB Recent guidelines for the treatment of hypoparathyroidism emphasize the need for long-term disease control, avoiding symptoms and hypocalcaemia. Our aim has been to analyze the prevalence of poor disease control in a national cohort of patients with hypoparathyroidism, as well as to evaluate predictive variables of inadequate disease control. From a nation-wide observational study including a cohort of 1792 patients undergoing total thyroidectomy, we selected 260 subjects [207 women and 53 men, aged (mean ± SD) 47.2±14.8 years] diagnosed with permanent hypoparathyroidism. In every patient demographic data and details on surgical procedure, histopathology, calcium (Ca) metabolism, and therapy with Ca and calcitriol were retrospectively collected. A patient was considered not adequately controlled (NAC) if presented symptoms of hypocalcemia or biochemical data showing low serum Ca levels or high urinary Ca excretion. Two hundred and twenty-one (85.0%) patients were adequately controlled (AC) and 39 (15.0%) were NAC. Comparison between AC and NAC patients did not show any significant difference in demographic, surgical, and pathological features. Rate of hospitalization during follow-up was significantly higher among NAC patients in comparison with AC patients (35.9% vs. 10.9%, P In a nation-wide cohort of 260 subjects with definitive hypoparathyroidism, 15% of them had poor disease control. These patients required higher doses of oral Ca and calcitriol, had higher rate of hospitalization during follow-up and showed lower PTH concentrations in the postoperative period.
SN 2227-684X
YR 2020
FD 2020
LK http://hdl.handle.net/10668/16649
UL http://hdl.handle.net/10668/16649
LA en
DS RISalud
RD Apr 18, 2025