%0 Journal Article
%A Díez, Juan J
%A Anda, Emma
%A Sastre, Julia
%A Pérez Corral, Begoña
%A Álvarez-Escolá, Cristina
%A Manjón, Laura
%A Paja, Miguel
%A Sambo, Marcel
%A Santiago Fernández, Piedad
%A Blanco Carrera, Concepción
%A Galofré, Juan C
%A Navarro, Elena
%A Zafón, Carles
%A Sanz, Eva
%A Oleaga, Amelia
%A Bandrés, Orosia
%A Donnay, Sergio
%A Megía, Ana
%A Picallo, María
%A Sánchez Ragnarsson, Cecilia
%A Baena-Nieto, Gloria
%A Fernández-García, José Carlos
%A Lecumberri, Beatriz
%A Sahún de la Vega, Manel
%A Romero-Lluch, Ana R
%A Iglesias, Pedro
%T Permanent postoperative hypoparathyroidism: an analysis of prevalence and predictive factors for adequacy of control in a cohort of 260 patients.
%D 2020
%@ 2227-684X
%U http://hdl.handle.net/10668/16649
%X Recent guidelines for the treatment of hypoparathyroidism emphasize the need for long-term disease control, avoiding symptoms and hypocalcaemia. Our aim has been to analyze the prevalence of poor disease control in a national cohort of patients with hypoparathyroidism, as well as to evaluate predictive variables of inadequate disease control. From a nation-wide observational study including a cohort of 1792 patients undergoing total thyroidectomy, we selected 260 subjects [207 women and 53 men, aged (mean ± SD) 47.2±14.8 years] diagnosed with permanent hypoparathyroidism. In every patient demographic data and details on surgical procedure, histopathology, calcium (Ca) metabolism, and therapy with Ca and calcitriol were retrospectively collected. A patient was considered not adequately controlled (NAC) if presented symptoms of hypocalcemia or biochemical data showing low serum Ca levels or high urinary Ca excretion. Two hundred and twenty-one (85.0%) patients were adequately controlled (AC) and 39 (15.0%) were NAC. Comparison between AC and NAC patients did not show any significant difference in demographic, surgical, and pathological features. Rate of hospitalization during follow-up was significantly higher among NAC patients in comparison with AC patients (35.9% vs. 10.9%, P In a nation-wide cohort of 260 subjects with definitive hypoparathyroidism, 15% of them had poor disease control. These patients required higher doses of oral Ca and calcitriol, had higher rate of hospitalization during follow-up and showed lower PTH concentrations in the postoperative period.
%K Permanent hypoparathyroidism
%K adequacy of control
%K parathyroid hormone (PTH)
%K thyroidectomy
%~