RT Journal Article
T1 Unusual anatomical origins of the coronary arteries in C57BL/6 mice. Are they strain-specific?
A1 Lopez-Garcia, Alejandro
A1 Soto-Navarrete, M Teresa
A1 Fernandez, M Carmen
A1 Moncayo-Arlandi, Javier
A1 Duran, Ana Carmen
A1 Lopez-Unzu, Miguel A
A1 Alonso-Briales, Juan Horacio
A1 Fernandez, Borja
K1 coronary arteries
K1 genetic background
K1 mouse
K1 strain
AB A previous manuscript [Fernández B, et al. (2008) J Anat 212, 12] reported on the unusual coronary artery patterns in mice belonging to the C57BL/6 strain. The aim here was to elucidate whether this pattern is unique to C57BL/6 mice or appears in other laboratory mouse strains and in wild-living mice. Stereomicroscopy, scanning electron microscopy, light microscopy and a corrosion cast technique were used to examine 597 adult mice belonging to three inbred strains (C57BL/6, Balb/c, DBA/2), three outbred stocks (CD1, OF1, NMRI) two hybrid lines (129sv × BL/6, CD2F1) and wild mice. It was shown that lock-like ostium is an exclusive trait of C57BL/6 mice, whereas left septal artery, accessory ostium, high take-off, intramural course and solitary ostium in aorta are all present in the different laboratory strains and wild mice included in the present study. However, each mouse population shows a specific incidence of these coronary conditions. Several clinically relevant human coronary artery anomalies are present in healthy mice from different strains that may serve as animal models for humans. These results should be taken into consideration in research concerning the murine coronary system, especially in coronary artery occlusion experiments and in studies on cardiovascular developmental biology using murine mutant lines.
PB Wiley
YR 2016
FD 2016-05-20
LK http://hdl.handle.net/10668/10217
UL http://hdl.handle.net/10668/10217
LA en
NO López-García A, Soto-Navarrete MT, Fernández MC, Moncayo-Arlandi J, Durán AC, López-Unzu MA, et al. Unusual anatomical origins of the coronary arteries in C57BL/6 mice. Are they strain-specific? J Anat. 2016 Nov;229(5):703-709
NO This work was supported by Grants PI-0888/2012 and PI-0591/2010from Junta de Andalucía (Sevilla, Spain); and Red de Investigación Cardiovascular (RIC; RETICs) (Madrid, Spain).
DS RISalud
RD Apr 8, 2025