TY - JOUR AU - Sayd, Aline AU - Antón, María AU - Alén, Francisco AU - Caso, Javier Rubén AU - Pavón, Javier AU - Leza, Juan Carlos AU - Rodríguez de Fonseca, Fernando AU - García-Bueno, Borja AU - Orio, Laura PY - 2015 DO - 10.1093/ijnp/pyu111 SN - 1461-1457 UR - http://hdl.handle.net/10668/2337 T2 - The International Journal of Neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) AB - BACKGROUNDThe acylethanolamides oleoylethanolamide and palmitoylethanolamide are endogenous lipid mediators with proposed neuroprotectant properties in central nervous system (CNS) pathologies. The precise mechanisms remain partly unknown, but growing... LA - en PB - Oxford University Press KW - OLEA KW - Lipopolysaccharide KW - Neuroinflammation KW - Anhedonia KW - Antiinflamatorios KW - Corticosterona KW - Citocinas KW - Modelos de enfermedad en animales KW - Encefalitis KW - Endocannabinoides KW - Endotoxinas KW - Etanolaminas KW - PEA KW - Preferencias alimenticias KW - Lóbulo frontal KW - Sistema hipotálamo-hipofisario KW - Mediadores de la inflamación KW - Peroxidación de lípidos KW - Fármacos neuroprotectores KW - Ácidos oleicos KW - Estrés oxidativo KW - Ácidos palmíticos KW - Sistema hipófiso-suprarrenal KW - Ratas wistar KW - Percepción del gusto KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavior, Animal KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Body Temperature Regulation KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain KW - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones::Hydroxycorticosteroids::11-Hydroxycorticosteroids::Corticosterone KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal KW - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Encephalitis KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Toxins, Biological::Bacterial Toxins::Endotoxins KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol::Ethanolamines KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Food Preferences KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex::Frontal Lobe KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Hypothalamus::Hypothalamus, Middle::Hypothalamo-Hypophyseal System KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Inflammation Mediators KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism::Oxidation-Reduction::Lipid Peroxidation KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective Agents KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Fatty Acids, Monounsaturated::Oleic Acids KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Stress, Physiological::Oxidative Stress KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Palmitic Acids KW - Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Pituitary-Adrenal System KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar KW - Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Perception::Taste Perception KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Neurobehavioral Manifestations::Anhedonia TI - Systemic administration of oleoylethanolamide protects from neuroinflammation and anhedonia induced by LPS in rats. TY - research article ER -