TY - JOUR AU - Kolijn, P Martijn AU - Hosnijeh, Fatemeh Saberi AU - Späth, Florentin AU - Hengeveld, Paul J AU - Agathangelidis, Andreas AU - Saleh, Manal AU - Casabonne, Delphine AU - Benavente, Yolanda AU - Jerkeman, Mats AU - Agudo, Antonio AU - Barricarte, Aurelio AU - Besson, Caroline AU - Sanchez-Perez, Maria-Jose AU - Chirlaque, María-Dolores AU - Masala, Giovanna AU - Sacerdote, Carlotta AU - Grioni, Sara AU - Schulze, Matthias B AU - Nieters, Alexandra AU - Engelfriet, Peter AU - Hultdin, Magnus AU - McKay, James D AU - Vermeulen, Roel C H AU - Langerak, Anton W PY - 2022 DO - 10.1182/blood.2021012890 UR - http://hdl.handle.net/10668/20244 T2 - Blood AB - Chronic lymphocytic leukemia (CLL) is preceded by monoclonal B-cell lymphocytosis (MBL), a CLL precursor state with a prevalence of up to 12% in aged individuals; however, the duration of MBL and the mechanisms of its evolution to CLL remain largely... LA - en PB - American Society of Hematology KW - Aged KW - B-Lymphocytes KW - Humans KW - Immunoglobulin Heavy Chains KW - Leukemia, Lymphocytic, Chronic, B-Cell KW - Lymphocytosis KW - Receptors, Antigen, B-Cell TI - High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis. TY - research article VL - 139 ER -