RT Journal Article
T1 Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome.
A1 Diaz-Lopez, Andres
A1 Paz-Graniel, Indira
A1 Ruiz, Veronica
A1 Toledo, Estefania
A1 Becerra-Tomas, Nerea
A1 Corella, Dolores
A1 Castañer, Olga
A1 Martinez, J Alfredo
A1 Alonso-Gomez, Angel M
A1 Warnberg, Julia
A1 Vioque, Jesus
A1 Romaguera, Dora
A1 Lopez-Miranda, Jose
A1 Estruch, Ramon
A1 Tinahones, Francisco J
A1 Lapetra, Jose
A1 Serra-Majem, Luis
A1 Bueno-Cavanillas, Aurora
A1 Tur, Josep A
A1 Sanchez, Vicente Martin
A1 Pinto, Xavier
A1 Delgado-Rodriguez, Miguel
A1 Matia-Martin, Pilar
A1 Vidal, Josep
A1 Vazquez, Clotilde
A1 Daimiel, Lidia
A1 Villa, Tania Fernandez
A1 Ros, Emilio
A1 Eguaras, Sonia
A1 Babio, Nancy
A1 Sorlí, Jose V
A1 Goday, Albert
A1 Abete, Itziar
A1 Sierra, Lucas Tojal
A1 Baron-Lopez, Francisco Javier
A1 Torres-Collado, Laura
A1 Morey, Marga
A1 Garcia-Rios, Antonio
A1 Casas, Rosa
A1 Bernal-Lopez, Maria Rosa
A1 Santos-Lozano, Jose Manuel
A1 Navarro, Adela
A1 Gonzalez, Jose I
A1 Zomeño, Maria Dolores
A1 Zulet, Maria Angeles
A1 Luna, Jessica Vaquero
A1 Ramallal, Raul
A1 Fito, Montse
A1 Salas-Salvado, Jordi
AB It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55-75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01-1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.
PB Nature Publishing Group
YR 2021
FD 2021-03-31
LK http://hdl.handle.net/10668/17621
UL http://hdl.handle.net/10668/17621
LA en
NO Díaz-López A, Paz-Graniel I, Ruiz V, Toledo E, Becerra-Tomás N, Corella D, et al.  Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome. Sci Rep. 2021 Apr 22;11(1):8719
NO We thank all the volunteers for the participation and personnel for the contribution in the PREDIMED-Plus trial. CIBEROBN, CIBERESP and CIBERDEM are initiatives of ISCIII, Madrid, Spain. Te authors also thank the PREDIMED-Plus Biobank Network as a part of the National Biobank Platform of the ISCIII for storing and managing the PREDIMED-Plus biological samples. Tis work was supported by the ofcial Spanish Institutions for funding scientifc biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (fve coordinated FIS projects leaded by JS-S and JVi, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus Grant to JS-S; the European Research Council (Advanced Research Grant 2014–2019; Agreement #340918) granted to MÁM-G.; the Recercaixa (Number 2013ACUP00194) grant to JS-S; grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 grant from the Generalitat Valenciana; the SEMERGEN grant; funds from the European Regional Development Fund (CB06/03); International Nut & Dried Fruit Council – FESNAD (Long-term efects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014 –2015, No. 201302) (PI: MÁM-G); the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (PI: DR); grant of support to research groups no. 35/2011 (Balearic Islands Gov.; FEDER funds) (JAT and CB); the JR17/00022 (ISCIII) grant to OC; the Boosting young talent call grant program for the development of IISPV research projects 2019–2021 (Ref.: 2019/IISPV/03 grant to AD-L); the Societat Catalana d’Endocrinologia i Nutrició (SCEN) Clinical-Research Grant 2019 (IPs: JS-S and AD-L). Collaborative Nutrition and/or Obesity Project for Young Researchers 2019 supported by CIBEROBN entitled: Lifestyle Interventions and Chronic Kidney Disease: Infammation, Oxidative Stress and Metabolomic Profle (LIKIDI study) grant toAD-L. IP-G receives a grant from the Spanish Ministry of Education, Culture and Sports (FPU17/01925). Jordi Salas-Salvadó, the senior author of this work, gratefully acknowledges the fnancial support by ICREA underthe ICREA Academia programme. None of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication.
DS RISalud
RD Apr 6, 2025