%0 Journal Article
%A Diaz-Lopez, Andres
%A Paz-Graniel, Indira
%A Ruiz, Veronica
%A Toledo, Estefania
%A Becerra-Tomas, Nerea
%A Corella, Dolores
%A Castañer, Olga
%A Martinez, J Alfredo
%A Alonso-Gomez, Angel M
%A Warnberg, Julia
%A Vioque, Jesus
%A Romaguera, Dora
%A Lopez-Miranda, Jose
%A Estruch, Ramon
%A Tinahones, Francisco J
%A Lapetra, Jose
%A Serra-Majem, Luis
%A Bueno-Cavanillas, Aurora
%A Tur, Josep A
%A Sanchez, Vicente Martin
%A Pinto, Xavier
%A Delgado-Rodriguez, Miguel
%A Matia-Martin, Pilar
%A Vidal, Josep
%A Vazquez, Clotilde
%A Daimiel, Lidia
%A Villa, Tania Fernandez
%A Ros, Emilio
%A Eguaras, Sonia
%A Babio, Nancy
%A Sorlí, Jose V
%A Goday, Albert
%A Abete, Itziar
%A Sierra, Lucas Tojal
%A Baron-Lopez, Francisco Javier
%A Torres-Collado, Laura
%A Morey, Marga
%A Garcia-Rios, Antonio
%A Casas, Rosa
%A Bernal-Lopez, Maria Rosa
%A Santos-Lozano, Jose Manuel
%A Navarro, Adela
%A Gonzalez, Jose I
%A Zomeño, Maria Dolores
%A Zulet, Maria Angeles
%A Luna, Jessica Vaquero
%A Ramallal, Raul
%A Fito, Montse
%A Salas-Salvado, Jordi
%T Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome.
%D 2021
%U http://hdl.handle.net/10668/17621
%X It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55-75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m2 greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m2 (95% CI 1.01-1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m2 greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.
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