RT Journal Article
T1 Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis.
A1 Ortiz, Miguel A
A1 Núñez, Concepción
A1 Ordóñez, David
A1 Alvarez-Cermeño, José C
A1 Martínez-Rodriguez, José E
A1 Sánchez, Antonio J
A1 Arroyo, Rafael
A1 Izquierdo, Guillermo
A1 Malhotra, Sunny
A1 Montalban, Xavier
A1 García-Merino, Antonio
A1 Munteis, Elvira
A1 Alcina, Antonio
A1 Comabella, Manuel
A1 Matesanz, Fuencisla
A1 Villar, Luisa M
A1 Urcelay, Elena
K1 Alelos
K1 Predisposición Genética a la Enfermedad
K1 Estudio de asociación genómica completa  Asociación del Genoma Completo
K1 Cadenas HLA-DRB1
K1 Complejo principal de histocompatibilidad
K1 Reacción en cadena de la polimerasa
K1 Esclerosis múltiple
AB BACKGROUNDMultiple sclerosis (MS) is a neurodegenerative, autoimmune disease of the central nervous system. Genome-wide association studies (GWAS) have identified over hundred polymorphisms with modest individual effects in MS susceptibility and they have confirmed the main individual effect of the Major Histocompatibility Complex. Additional risk loci with immunologically relevant genes were found significantly overrepresented. Nonetheless, it is accepted that most of the genetic architecture underlying susceptibility to the disease remains to be defined. Candidate association studies of the leukocyte immunoglobulin-like receptor LILRA3 gene in MS have been repeatedly reported with inconsistent results.OBJECTIVESIn an attempt to shed some light on these controversial findings, a combined analysis was performed including the previously published datasets and three newly genotyped cohorts. Both wild-type and deleted LILRA3 alleles were discriminated in a single-tube PCR amplification and the resulting products were visualized by their different electrophoretic mobilities.RESULTS AND CONCLUSIONOverall, this meta-analysis involved 3200 MS patients and 3069 matched healthy controls and it did not evidence significant association of the LILRA3 deletion [carriers of LILRA3 deletion: p = 0.25, OR (95% CI) = 1.07 (0.95-1.19)], even after stratification by gender and the HLA-DRB1*15:01 risk allele.
PB Public Library of Science
YR 2015
FD 2015-08-14
LK http://hdl.handle.net/10668/2012
UL http://hdl.handle.net/10668/2012
LA en
NO Ortiz MA, Núñez C, Ordóñez D, Alvarez-Cermeño JC, Martínez-Rodriguez JE, Sánchez AJ, et al. Influence of the LILRA3 Deletion on Multiple Sclerosis Risk: Original Data and Meta-Analysis. PLoS ONE. 2015; 10(8):e0134414
NO Journal Article;
DS RISalud
RD Mar 14, 2025