RT Journal Article
T1 Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor.
A1 Balsa, Alejandro
A1 Cabezón, Arancha
A1 Orozco, Gisela
A1 Cobo, Tatiana
A1 Miranda-Carus, Eugenia
A1 López-Nevot, Miguel Angel
A1 Vicario, José Luis
A1 Martín-Mola, Emilio
A1 Martín, Javier
A1 Pascual-Salcedo, Dora
K1 Secuencias de Aminoácidos
K1 Artritis Reumatoide
K1 Autoanticuerpos
K1 Epítopos
K1 Femenino
K1 Marcadores Genéticos
K1 Predisposición Genética a la Enfermedad
K1 Antígenos HLA-DR
K1 Cadenas HLA-DRB1
K1 Humanos
K1 Masculino
K1 Mediana Edad
K1 Péptidos Cíclicos
K1 Conformación Proteica
K1 Factor Reumatoide
AB INTRODUCTIONThe purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF).METHODSWe studied 408 patients (235 with RA, 173 non-RA) and 269 controls. ACPA, RF and HLA-DR typing were determined.RESULTSWe found an increased frequency of HLA DRB1 alleles with the shared epitope (SE) in ACPA-positive RA. Inversely, HLA DRB1 alleles encoding DERAA sequences were more frequent in controls than in ACPA-positive RA, and a similar trend was found for HLA DR3. However, these results could not be confirmed after stratification for the presence of the SE, probably due to the relatively low number of patients. These data may suggest that the presence of these alleles may confer a protective role for ACPA-positive RA. In RA patients we observed association between SE alleles and ACPA titers in a dose-dependent effect. The presence of HLA DR3 or DERAA-encoding alleles was associated with markedly reduced ACPA levels. No association between RF titers and HLA DR3 or DERAA-encoding alleles was found.CONCLUSIONSHLA DRB1 alleles with the SE are associated with production of ACPA. DERAA-encoding HLA-DR alleles and HLA DR3 may be protective for ACPA-positive RA.
PB BioMed Central
SN 1478-6354
YR 2010
FD 2010-04-06
LK http://hdl.handle.net/10668/634
UL http://hdl.handle.net/10668/634
LA en
NO Balsa A, Cabezón A, Orozco G, Cobo T, Miranda-Carus E, López-Nevot MA, et al. Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor. Arthritis Res. Ther.; 12(2):R62
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 8, 2025