RT Journal Article T1 Proposal for assessment of the predominant symptom and physical function in patients suffering from Long COVID A1 Roldan-Jimenez, Cristina A1 Cuesta-Vargas, Antonio, I K1 Long COVID K1 Symptom assessment K1 Postviral fatigue syndrome K1 Systemic exertion intolerance disease K1 Viral infection K1 Chronic-fatigue-syndrome K1 Survivors AB Long COVID patients present a cluster of symptoms that overlaps with other post-infectious conditions, such as patients diagnosed with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Besides fatigue, one of the most limiting clinical manifestations in ME/CFS is post-exertional malaise (PEM), which Long COVID patients also report. Therefore, there are concerns about treatment approaches in rehabilitation for long COVID patients. Up to date, Long COVID patients present fatigue and respiratory symptoms predominantly. The hypothesis presented in this paper is that the treatment approach for Long COVID patients may depend on the aetiology of their symptoms, which objective tests can assess. And the primary affected system in a given patient may determine the individual response to physical exhaustion. Then, we propose an assessment to confirm the system impaired under the predominant symptom to guide the rehabilitation intervention. Fatigue-related symptoms, PEM, physical deconditioning and response to exertion should be assessed in Long COVID patients with predominant fatigue. In contrast, the respiratory function by spirometry and the diffusion capacity should be objectively assessed in those patients with predominantly respiratory symptoms. Future research should develop and validate patient-reported outcomes or cardiopulmonary exercise testing to objectively assess the symptoms and functional status in Long COVID patients to reinforce the proposed assessment. PB Elsevier SN 0306-9877 YR 2022 FD 2022-03-01 LK http://hdl.handle.net/10668/22389 UL http://hdl.handle.net/10668/22389 LA en NO Roldán-Jiménez C, Cuesta-Vargas AI. Proposal for assessment of the predominant symptom and physical function in patients suffering from Long COVID. Med Hypotheses.2022;162(110811):110811 DS RISalud RD Apr 9, 2025