RT Journal Article
T1 Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine-1 Trial).
A1 Cruz-Chamorro, Ivan
A1 Alvarez-Sanchez, Nuria
A1 Alvarez-Rios, Ana Isabel
A1 Santos-Sanchez, Guillermo
A1 Pedroche, Justo
A1 Millan, Francisco
A1 Carrera Sanchez, Cecilio
A1 Fernandez-Pachon, Maria Soledad
A1 Millan-Linares, Maria Carmen
A1 Martinez-Lopez, Alicia
A1 Lardone, Patricia Judith
A1 Bejarano, Ignacio
A1 Guerrero, Juan Miguel
A1 Carrillo-Vico, Antonio
K1 cholesterol
K1 hydrolysate
K1 inflammation
K1 lupine
K1 oxidative stress
AB We have previously demonstrated the anti-inflammatory and antioxidant properties of in vitro administered Lupinus angustifolius protein hydrolysates (LPHs) on human peripheral blood mononuclear cells (PBMCs). This study aims to evaluate the safety and efficacy of a beverage containing LPHs (LPHb) on the immune, oxidative and metabolic status of healthy subjects. In this open-label intervention, 33 participants daily ingest a LPHb containing 1 g LPHs for 28 days. Biochemical parameters are assayed in fasting peripheral blood and urine samples before, during (14 days) and after LPHb ingestion. Participants' health status and the immune and antioxidant responses of PBMCs are also evaluated throughout the trial. The LPHb ingestion is safe and effective in both increasing the anti-/pro-inflammatory response of PBMCs and improving the cellular anti-oxidant capacity. LPHb also reduces the low-density lipoprotein-cholesterol (LDL-C)/high-density lipoprotein-cholesterol (HDL-C) atherogenic index. LPHb effect is particularly beneficial on decreasing not only the LDL-C/HDL-C index but also serum total cholesterol levels in the male cohort that shows the highest baseline levels of well-known cardiovascular risk factors. This is the first study to show the pleiotropic actions of a lupine bioactive peptides-based functional food on key steps of atherosclerosis including inflammation, oxidative stress, and cholesterol metabolism.
PB Wiley-VCH Verlag GmbH & Co. KGaA
YR 2021
FD 2021-07-21
LK http://hdl.handle.net/10668/17809
UL http://hdl.handle.net/10668/17809
LA en
NO Cruz-Chamorro I, Álvarez-Sánchez N, Álvarez-Ríos AI, Santos-Sánchez G, Pedroche J, Millán F, et al.  Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine-1 Trial). Mol Nutr Food Res. 2021 Jul;65(14):e2100139.
NO This work was supported by the Spanish Government, Ministerio de Economía y Competitividad [AGL2012-40247-C02-01 and AGL2012-40247-C02-02], the Andalusian Government Ministry of Health [PC-0111-2016-0111] and the PAIDI Program from the Andalusian Government [CTS160]. IC-C and GS-S were supported by FPU grants from the Spanish Ministerio de Educación, Cultura y Deporte, [FPU13/01210 and FPU16/02339, respectively]. NA-S was supported by fellowships from the National Net RETICEF for Aging Studies [Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad; RD06/0013/0001 and RD12/0043/0012; from the Instituto de Salud Carlos III, Spanish Ministerio de Ciencia e Innovación]. AML was supported by a PIF grant from the V Program of Inner Initiative for Research and Transfer of University of Seville [V PPIT-US]. I-B was granted by the VI Program of Inner Initiative for Research and Transfer of University of Seville [VI PPIT-US]. The authors thank John Leslie Brown for editing the manuscript.
DS RISalud
RD Apr 8, 2025