TY - JOUR AU - Elez, Elena AU - Gomez-España, Maria Auxiliadora AU - Gravalos, Cristina AU - Garcia-Alfonso, Pilar AU - Ortiz-Morales, Maria Jose AU - Losa, Ferran AU - Diaz, Inmaculada Ales AU - Graña, Begoña AU - Toledano-Fonseca, Marta AU - Valladares-Ayerbes, Manuel AU - Polo, Eduardo AU - Salgado, Mercedes AU - Martinez de Castro, Eva AU - Safont, Maria Jose AU - Salud, Antonieta AU - Ruiz-Casado, Ana AU - Tabernero, Josep AU - Riesco, Maria Del Carmen AU - Rodriguez-Ariza, Antonio AU - Aranda, Enrique PY - 2021 DO - 10.1038/s41416-021-01638-w UR - http://hdl.handle.net/10668/19521 T2 - British journal of cancer AB - Aflibercept is an antiangiogenic drug against metastatic colorectal cancer (mCRC) combined with 5-fluorouracil/leucovorin/irinotecan (FOLFIRI); however, no antiangiogenic biomarker has yet been validated. We assessed aflibercept plus FOLFIRI,... LA - en PB - Nature KW - Biomarkers KW - Colorectal neoplasms KW - Fluorouracil KW - Vascular endothelial growth factor A KW - Antineoplastic combined chemotherapy protocols KW - Biomarkers KW - Camptothecin KW - Colorectal neoplasms KW - Fluorouracil KW - Humans KW - Irinotecan KW - Leucovorin KW - Receptors, vascular endothelial growth factor KW - Recombinant fusion proteins KW - Vascular endothelial growth factor A TI - Effect of aflibercept plus FOLFIRI and potential efficacy biomarkers in patients with metastatic colorectal cancer: the POLAF trial. TY - research article VL - 126 ER -