RT Journal Article
T1 Paulomycin G, a New Natural Product with Cytotoxic Activity against Tumor Cell Lines Produced by Deep-Sea Sediment Derived Micromonospora matsumotoense M-412 from the Aviles Canyon in the Cantabrian Sea
A1 Sarmiento-Vizcaino, Aida
A1 Brana, Alfredo F.
A1 Perez-Victoria, Ignacio
A1 Martin, Jesus
A1 de Pedro, Nuria
A1 de la Cruz, Mercedes
A1 Diaz, Caridad
A1 Vicente, Francisca
A1 Acuna, Jose L.
A1 Reyes, Fernando
A1 Garcia, Luis A.
A1 Blanco, Gloria
K1 paulomycins
K1 Micromonospora
K1 antitumor
K1 Cantabrian Sea-derived actinobacteria
K1 Streptomyces-albus
K1 Strategies
K1 Antitumor
K1 Sponge
AB The present article describes a structurally novel natural product of the paulomycin family, designated as paulomycin G (1), obtained from the marine strain Micromonospora matsumotoense M-412, isolated from Cantabrian Sea sediments collected at 2000 m depth during an oceanographic expedition to the submarine Avils Canyon. Paulomycin G is structurally unique since-to our knowledge-it is the first member of the paulomycin family of antibiotics lacking the paulomycose moiety. It is also the smallest bioactive paulomycin reported. Its structure was determined using HRMS and 1D and 2D NMR spectroscopy. This novel natural product displays strong cytotoxic activities against different human tumour cell lines, such as pancreatic adenocarcinoma (MiaPaca2), breast adenocarcinoma (MCF-7), and hepatocellular carcinoma (HepG2). The compound did not show any significant bioactivity when tested against a panel of bacterial and fungal pathogens.
PB Mdpi
YR 2017
FD 2017-09-01
LK http://hdl.handle.net/10668/19300
UL http://hdl.handle.net/10668/19300
LA en
DS RISalud
RD Apr 6, 2025