TY  - JOUR
AU  - García-Argüello, Segundo Francisco
AU  - Lopez-Lorenzo, Beatriz
AU  - Cornelissen, Bart
AU  - Smith, Graham
PY  - 2020
DO  - 10.3390/cancers12082191
UR  - http://hdl.handle.net/10668/4148
T2  - Cancers
AB  - Insufficient apoptosis is a recognised hallmark of cancer. A strategy to quantitatively measure apoptosis in vivo would be of immense value in both drug discovery and routine patient management. The first irreversible step in the apoptosis cascade is...
LA  - en
PB  - MDPI
KW  - Positron emission tomography
KW  - Apoptosis
KW  - Caspase-3
KW  - [18F]ICMT-11
KW  - Pyrimidoindolone
KW  - Michael acceptor
KW  - Neoplasms
KW  - Isatin
KW  - Tomografía de emisión de positrones
KW  - Caspasa-3
KW  - Neoplasias
KW  - Isatina
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases::Caspases::Caspases, Effector::Caspase 3
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles::Isatin
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Radioisotope::Radionuclide Imaging::Tomography, Emission-Computed::Positron-Emission...
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::NADH, NADPH Oxidoreductases::Apoptosis Inducing Factor
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Sulfonamides
KW  - Medical Subject Headings::Diseases::Neoplasms
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Drug Discovery
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
TI  - Development of [18F]ICMT-11 for Imaging Caspase-3/7 Activity during Therapy-Induced Apoptosis
TY  - review article
ER  -