TY - JOUR AU - Carranza, Diana AU - Torres-Rusillo, Sara AU - Ceballos-Pérez, Gloria AU - Blanco-Jimenez, Eva AU - Muñoz-López, Martin AU - García-Pérez, José L AU - Molina, Ignacio J PY - 2018 DO - 10.3389/fimmu.2018.02703 UR - http://hdl.handle.net/10668/13281 T2 - Frontiers in immunology AB - Ataxia-telangiectasia (A-T) is a complex disease arising from mutations in the ATM gene (Ataxia-Telangiectasia Mutated), which plays crucial roles in repairing double-strand DNA breaks (DSBs). Heterogeneous immunodeficiency, extreme radiosensitivity,... LA - en KW - Ataxia-Telangiectasia KW - Primary immunodeficiency KW - cell reconstitution KW - gene therapy KW - lentiviral vectors KW - monogenic diseases KW - Ataxia Telangiectasia KW - Ataxia Telangiectasia Mutated Proteins KW - Cell Line KW - Fibroblasts KW - Genetic Vectors KW - Lentivirus KW - Mutation KW - Transduction, Genetic TI - Reconstitution of the Ataxia-Telangiectasia Cellular Phenotype With Lentiviral Vectors. TY - research article VL - 9 ER -