RT Journal Article
T1 Angiogenesis-related gene expression profile with independent prognostic value in advanced ovarian carcinoma.
A1 Mendiola, Marta
A1 Barriuso, Jorge
A1 Redondo, Andrés
A1 Mariño-Enríquez, Adrián
A1 Madero, Rosario
A1 Espinosa, Enrique
A1 Fresno Vara, Juan Angel
A1 Sánchez-Navarro, Iker
A1 Hernández-Cortes, Ginés
A1 Zamora, Pilar
A1 Pérez-Fernández, Elia
A1 Miguel-Martín, María
A1 Suárez, Asunción
A1 Palacios, José
A1 González-Barón, Manuel
A1 Hardisson, David
K1 Anciano
K1 Anciano de 80 o más Años
K1 Carcinoma
K1 Femenino
K1 Perfilación de la Expresión Génica
K1 Regulación Neoplásica de la Expresión Génica
K1 Humanos
K1 Análisis Multivariante
K1 Neoplasias Ováricas
K1 Pronóstico
K1 ARN
K1 Neovascularización patológica
AB BACKGROUNDOvarian carcinoma is the most important cause of gynecological cancer-related mortality in Western societies. Despite the improved median overall survival in patients receiving chemotherapy regimens such as paclitaxel and carboplatin combination, relapse still occurs in most advanced diseased patients. Increased angiogenesis is associated with rapid recurrence and decreased survival in ovarian cancer. This study was planned to identify an angiogenesis-related gene expression profile with prognostic value in advanced ovarian carcinoma patients.METHODOLOGY/PRINCIPAL FINDINGSRNAs were collected from formalin-fixed paraffin-embedded samples of 61 patients with III/IV FIGO stage ovarian cancer who underwent surgical cytoreduction and received a carboplatin plus paclitaxel regimen. Expression levels of 82 angiogenesis related genes were measured by quantitative real-time polymerase chain reaction using TaqMan low-density arrays. A 34-gene-profile which was able to predict the overall survival of ovarian carcinoma patients was identified. After a leave-one-out cross validation, the profile distinguished two groups of patients with different outcomes. Median overall survival and progression-free survival for the high risk group was 28.3 and 15.0 months, respectively, and was not reached by patients in the low risk group at the end of follow-up. Moreover, the profile maintained an independent prognostic value in the multivariate analysis. The hazard ratio for death was 2.3 (95% CI, 1.5 to 3.2; p<0.001).CONCLUSIONS/SIGNIFICANCEIt is possible to generate a prognostic model for advanced ovarian carcinoma based on angiogenesis-related genes using formalin-fixed paraffin-embedded samples. The present results are consistent with the increasing weight of angiogenesis genes in the prognosis of ovarian carcinoma.
PB Public Library of Science
YR 2008
FD 2008-12-29
LK http://hdl.handle.net/10668/1704
UL http://hdl.handle.net/10668/1704
LA en
NO Mendiola M, Barriuso J, Redondo A, Mariño-Enríquez A, Madero R, Espinosa E, et al. Angiogenesis-related gene expression profile with independent prognosticvalue in advanced ovarian carcinoma. Plos One; 2008; 3(12):e40518
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 16, 2025