RT Journal Article
T1 Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study.
A1 Fernández-Cidón, Bárbara
A1 Candás-Estébanez, Beatriz
A1 Gil-Serret, Miriam
A1 Amigó, Núria
A1 Corbella, Emili
A1 Rodríguez-Sánchez, M Ángeles
A1 Padró-Miquel, Ariadna
A1 Brotons, Carlos
A1 Hernández-Mijares, Antonio
A1 Calmarza, Pilar
A1 Jarauta, Estibaliz
A1 Brea, Angel J
A1 Mauri, Marta
A1 Guijarro, Carlos
A1 Vila, Àlex
A1 Valdivielso, Pedro
A1 Corbella, Xavier
A1 Pintó, Xavier
K1 NMR analysis of lipoproteins
K1 lipid profile
K1 lipoprotein particle number
K1 lipoprotein precipitation
K1 premature cardiovascular disease
K1 residual cardiovascular risk
K1 small dense LDL
AB Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.
SN 2077-0383
YR 2021
FD 2021-03-29
LK https://hdl.handle.net/10668/26533
UL https://hdl.handle.net/10668/26533
LA en
DS RISalud
RD Apr 7, 2025