%0 Journal Article
%A Zozaya, Néboa
%A Arrizubieta Basterrechea, Maria Iciar
%A Bollo, Elena
%A Castellví, Iván
%A Espín, Jaime
%A Ortego, Norberto
%A Poveda-Andrés, José Luis
%A Rodríguez Portal, José Antonio
%A Rivero, Agustín
%A Marcos-Rodríguez, José Antonio
%A Verde, Luis
%T A multi-criteria decision analysis on the value of nintedanib for interstitial lung diseases.
%D 2022
%U http://hdl.handle.net/10668/22578
%X Our aim was to assess the value of nintedanib for non-idiopathic progressive fibrosing interstitial lung disease (non-IPF PF-ILD) and systemic sclerosis-associated ILD (SSc-ILD) in the Spanish context, using a multi-criteria decision analysis (MCDA). Following an adaptation of the Evidence and Value: Impact on DEcision Making (EVIDEM) MCDA methodology, the estimated value of nintedanib was obtained by means of an additive linear model that combined individual weights (100-points distribution) of criteria with the individual scoring of nintedanib in each criterion for every indication, assigned by a multidisciplinary committee of twelve clinicians, patients, pharmacists, and decision-makers. To assess the reproducibility, an alternative weighting method was applied, as well as a re-test of weights and scores at a different moment of time. The experts committee recognized nintedanib as an intervention with a positive value contribution in comparison to placebo for the treatment of non-IPF PF-ILD (0.50 ± 0.16, on a scale from -1 to 1) and SSc-ILD (0.40 ± 0.12), diseases which were considered as very severe and with high unmet needs. The drug was perceived as a treatment that provides an added therapeutic benefit for patients (0.06-0.07), given its proven clinical efficacy (0.05-0.06), slight improvements in patient-reported outcomes (0.01-0.02), and similar safety profile than placebo (-0.04-0.00), which will likely be positioned as a recommended therapy in the next clinical practice guidelines updates. Under this increasingly used methodology, nintedanib has shown to provide a positive value estimate for non-IPF PF-ILD and SSc-ILD when compared to placebo in Spain.
%K Interstitial lung diseases
%K Multi-criteria decision analysis
%K Pulmonary fibrosis
%K Systemic sclerosis
%~