RT Journal Article
T1 Mortality comparison between the first and second/third waves among 3,795 critical COVID-19 patients with pneumonia admitted to the ICU: A multicentre retrospective cohort study
A1 Carbonell, Raquel
A1 Urgeles, Silvia
A1 Rodriguez, Alejandro
A1 Bodi, Maria
A1 Martin-Loeches, Ignacio
A1 Sole-Violan, Jordi
A1 Diaz, Emili
A1 Gomez, Josep
A1 Trefler, Sandra
A1 Vallverdu, Montserrat
A1 Murcia, Josefa
A1 Albaya, Antonio
A1 Loza, Ana
A1 Socias, Lorenzo
A1 Carlos Ballesteros, Juan
A1 Papiol, Elisabeth
A1 Vina, Lucia
A1 Sancho, Susana
A1 Nieto, Mercedes
A1 del Carmen Lorente, Maria
A1 Badallo, Oihane
A1 Fraile, Virginia
A1 Armestar, Fernando
A1 Estella, Angel
A1 Sanchez, Laura
A1 Sancho, Isabel
A1 Margarit, Antonio
A1 Moreno, Gerard
A1 COVID-19 SEMICYUC Working Grp, 
AB Background: It is unclear whether the changes in critical care throughout the pandemic have improved the outcomes in coronavirus disease 2019 (COVID-19) patients admitted to the intensive care units (ICUs).Methods: We conducted a retrospective cohort study in adults with COVID-19 pneumonia admitted to 73 ICUs from Spain, Andorra and Ireland between February 2020 and March 2021. The first wave corresponded with the period from February 2020 to June 2020, whereas the second/third waves occurred from July 2020 to March 2021. The primary outcome was ICU mortality between study periods. Mortality predictors and differences in mortality between COVID-19 waves were identified using logistic regression.Findings: As of March 2021, the participating ICUs had included 3795 COVID-19 pneumonia patients, 2479 (65.3%) and 1316 (34.7%) belonging to the first and second/third waves, respectively. Illness severity scores predicting mortality were lower in the second/third waves compared with the first wave according with the Acute Physiology and Chronic Health Evaluation system (median APACHE II score 12 [IQR 9-16] vs 14 [IQR 10-19]) and the organ failure assessment score (median SOFA 4 [3-6] vs 5 [3-7], p
PB Elsevier
SN 2666-7762
YR 2021
FD 2021-11-04
LK https://hdl.handle.net/10668/25115
UL https://hdl.handle.net/10668/25115
LA en
DS RISalud
RD Apr 12, 2025