RT Journal Article
T1 Breast Cancer and Anaesthesia: Genetic Influence.
A1 Raigon-Ponferrada, Aida
A1 Guerrero-Orriach, Jose Luis
A1 Molina-Ruiz, Juan Carlos
A1 Romero-Molina, Salvador
A1 Gómez-Luque, Aurelio
A1 Cruz-Mañas, Jose
K1 anaesthetic drugs and techniques
K1 biomarkers
K1 breast cancer
K1 cancer recurrence
K1 miRNA
K1 opioids
K1 propofol
K1 volatile agent
AB Breast cancer is the leading cause of mortality in women. It is a heterogeneous disease with a high degree of inter-subject variability even in patients with the same type of tumor, with individualized medicine having acquired significant relevance in this field. The clinical and morphological heterogeneity of the different types of breast tumors has led to a diversity of staging and classification systems. Thus, these tumors show wide variability in genetic expression and prognostic biomarkers. Surgical treatment is essential in the management of these patients. However, the perioperative period has been found to significantly influence survival and cancer recurrence. There is growing interest in the pro-tumoral effect of different anaesthetic and analgesic agents used intraoperatively and their relationship with metastatic progression. There is cumulative evidence of the influence of anaesthetic techniques on the physiopathological mechanisms of survival and growth of the residual neoplastic cells released during surgery. Prospective randomized clinical trials are needed to obtain quality evidence on the relationship between cancer and anaesthesia. This document summarizes the evidence currently available about the effects of the anaesthetic agents and techniques used in primary cancer surgery and long-term oncologic outcomes, and the biomolecular mechanisms involved in their interaction.
PB MDPI
YR 2021
FD 2021-07-17
LK http://hdl.handle.net/10668/18243
UL http://hdl.handle.net/10668/18243
LA en
NO Raigon Ponferrada A, Guerrero Orriach JL, Molina Ruiz JC, Romero Molina S, Gómez Luque A, Cruz Mañas J. Breast Cancer and Anaesthesia: Genetic Influence. Int J Mol Sci. 2021 Jul 17;22(14):7653
DS RISalud
RD Apr 11, 2025