RT Journal Article
T1 New signatures of poor CD4 cell recovery after suppressive antiretroviral therapy in HIV-1-infected individuals: involvement of miR-192, IL-6, sCD14 and miR-144
A1 Hernández-Walias, Francisco
A1 Ruiz-de-León, María J.
A1 Rosado-Sánchez, Isaac
A1 Vázquez, Esther
A1 Leal, Manuel
A1 Moreno, Santiago
A1 Vidal, Francesc
A1 Blanco, Julià
A1 Pacheco, Yolanda M.
A1 Vallejo, Alejandro
K1 HIV-1
K1 Multivariate analysis
K1 Cell recovery
K1 MicroRNAs
K1 Antiretroviral therapy
K1 Cytokines
K1 VIH-1
K1 Análisis multivariante
K1 MicroARNs
K1 Citocinas
AB Up to 40% of newly diagnosed cases of HIV-1 infection are late diagnoses, with a profound decrease in CD4 cell counts in many cases. One-third of these individuals do not achieve optimal CD4 cell recovery (OR) after suppressive antiretroviral treatment (ART). This retrospective/longitudinal study of poor recovery (PR) included 79 HIV-1-infected individuals with CD4 count <200 cells/mm3 (25 PR and 54 OR) before ART. After suppressive ART, 21 PR and 24 OR individuals were further analysed, including paired samples. Selected miRs and plasma inflammatory markers were determined to investigate their potential predictive/diagnostic value for poor recovery. miR-192, IL-6 and sCD14 were independently associated with CD4 recovery before ART (p = 0.031, p = 0.007, and p = 0.008, respectively). The combination of these three factors returned a good discrimination (predictive value for PR) value of 0.841 (AUC, p < 0.001). After suppressive ART, miR-144 was independently associated with CD4 recovery (p = 0.017), showing a moderate discrimination value of 0.730 (AUC, p = 0.008) for PR. Our study provides new evidence on the relationship between miRs and HIV-1 infection that could help improve the management of individuals at HIV-1 diagnosis. These miRs and cytokines signature sets provide novel tools to predict CD4 cell recovery and its progression after ART.
PB Springer Nature
YR 2020
FD 2020-02-19
LK http://hdl.handle.net/10668/4434
UL http://hdl.handle.net/10668/4434
LA en
NO Hernández-Walias F, Ruiz-de-León MJ, Rosado-Sánchez I, Vázquez E, Leal M, Moreno S, et al. New signatures of poor CD4 cell recovery after suppressive antiretroviral therapy in HIV-1-infected individuals: involvement of miR-192, IL-6, sCD14 and miR-144. Sci Rep. 2020 Feb 19;10(1):2937
DS RISalud
RD Apr 19, 2025