RT Journal Article
T1 Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
A1 Abumayyaleh, Mohammad
A1 Nunez-Gil, Ivan J.
A1 El-Battrawy, Ibrahim
A1 Estrada, Vicente
A1 Manuel Becerra-Munoz, Victor
A1 Uribarri, Aitor
A1 Fernandez-Rozas, Inmaculada
A1 Feltes, Gisela
A1 Arroyo-Espliguero, Ramon
A1 Trabattoni, Daniela
A1 Lopez Pais, Javier
A1 Pepe, Martino
A1 Romero, Rodolfo
A1 Elizabeth Ortega-Armas, Maria
A1 Bianco, Matteo
A1 Capel Astrua, Thamar
A1 D'Ascenzo, Fabrizio
A1 Fabregat-Andres, Oscar
A1 Ballester, Andrea
A1 Marin, Francisco
A1 Buonsenso, Danilo
A1 Sanchez-Gimenez, Raul
A1 Weiss, Christel
A1 Fernandez Perez, Cristina
A1 Fernandez-Ortiz, Antonio
A1 Macaya, Carlos
A1 Akin, Ibrahim
A1 HOPE COVID-19 Investigators, 
K1 sepsis
K1 score
K1 COVID-19
K1 SARS-CoV-2
K1 outcome
K1 Consensus definitions
K1 Pneumonia
AB Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus.Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO(2)) 22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO(2)) 1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1-11.8%); intermediate-risk group (24.8-53.8%); and high-risk-group (58.3-100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO(2), decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis.Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.
PB Frontiers media sa
YR 2021
FD 2021-10-14
LK https://hdl.handle.net/10668/26921
UL https://hdl.handle.net/10668/26921
LA en
DS RISalud
RD Apr 11, 2025