%0 Journal Article
%A Abumayyaleh, Mohammad
%A Nunez-Gil, Ivan J.
%A El-Battrawy, Ibrahim
%A Estrada, Vicente
%A Manuel Becerra-Munoz, Victor
%A Uribarri, Aitor
%A Fernandez-Rozas, Inmaculada
%A Feltes, Gisela
%A Arroyo-Espliguero, Ramon
%A Trabattoni, Daniela
%A Lopez Pais, Javier
%A Pepe, Martino
%A Romero, Rodolfo
%A Elizabeth Ortega-Armas, Maria
%A Bianco, Matteo
%A Capel Astrua, Thamar
%A D'Ascenzo, Fabrizio
%A Fabregat-Andres, Oscar
%A Ballester, Andrea
%A Marin, Francisco
%A Buonsenso, Danilo
%A Sanchez-Gimenez, Raul
%A Weiss, Christel
%A Fernandez Perez, Cristina
%A Fernandez-Ortiz, Antonio
%A Macaya, Carlos
%A Akin, Ibrahim
%A HOPE COVID-19 Investigators
%T Sepsis of Patients Infected by SARS-CoV-2: Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
%D 2021
%U https://hdl.handle.net/10668/26921
%X Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19.Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus.Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO(2)) 22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO(2)) 1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1-11.8%); intermediate-risk group (24.8-53.8%); and high-risk-group (58.3-100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO(2), decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis.Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.
%K sepsis
%K score
%K COVID-19
%K SARS-CoV-2
%K outcome
%K Consensus definitions
%K Pneumonia
%~