RT Journal Article
T1 IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).
A1 Alcina, Antonio
A1 Fedetz, María
A1 Ndagire, Dorothy
A1 Fernández, Oscar
A1 Leyva, Laura
A1 Guerrero, Miguel
A1 Abad-Grau, María M
A1 Arnal, Carmen
A1 Delgado, Concepción
A1 Lucas, Miguel
A1 Izquierdo, Guillermo
A1 Matesanz, Fuencisla
K1 Alelos
K1 Mapeo cromosómico
K1 Diabetes mellitus tipo I
K1 Predisposición genética a la enfermedad
K1 Genotipo
K1 Subunidad alfa del receptor de interleucina-2
K1 Desequilibrio de ligamiento
K1 Esclerosis múltiple
K1 Polimorfismo de Nucleótido Simple
AB BACKGROUND:IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity.METHODS AND RESULTS:Here we perform a replication and fine mapping of the IL2RA gene region analyzing 3 SNPs previously associated with multiple sclerosis (MS) and 5 SNPs associated with type 1 diabetes (T1D) in a collection of 798 MS patients and 927 matched Caucasian controls from the south of Spain. We observed association with MS in 6 of 8 SNPs. The rs1570538, at the 3'- UTR extreme of the gene, previously reported to have a weak association with MS, is replicated here (P = 0.032). The most associated T1D SNP (rs41295061) was not associated with MS in the present study. However, the rs35285258, belonging to another independent group of SNPs associated with T1D, showed the maximal association in this study but different risk allele. We replicated the association of only one (rs2104286) of the two IL2RA SNPs identified in the recently performed genome-wide association study of MS.CONCLUSIONS:These findings confirm and extend the association of this gene with MS and reveal a genetic heterogeneity of the associated polymorphisms and risk alleles between MS and T1D suggesting different immunopathological roles of IL2RA in these two diseases.
PB Public Library of Science
YR 2009
FD 2009-01-06
LK http://hdl.handle.net/10668/1288
UL http://hdl.handle.net/10668/1288
LA en
NO Alcina A, Fedetz M, Ndagire D, Fernández O, Leyva L, Guerrero M, et al. IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D). PLoS ONE. 2009; 4(1):e4137
DS RISalud
RD Apr 12, 2025