TY - JOUR AU - Villalba-Benito, Leticia AU - Torroglosa, Ana AU - Fernandez, Raquel Maria AU - Ruiz-Ferrer, Macarena AU - Moya-Jimenez, Maria Jose AU - AntiƱolo, Guillermo AU - Borrego, Salud PY - 2017 DO - 10.1038/s41598-017-06539-8 UR - http://hdl.handle.net/10668/11433 T2 - Scientific reports AB - Hirschsprung disease (HSCR) is attributed to a failure of neural crest cells (NCCs) to migrate, proliferate, differentiate and/or survive in the bowel wall during embryonic Enteric Nervous System (ENS) development. ENS formation is the result from a... LA - en PB - Nature Publishing Group KW - Age of Onset KW - Case-Control Studies KW - Enteric Nervous System KW - Gene Expression Regulation KW - Infant KW - Neural Crest KW - Animals KW - Biomarkers KW - Child, Preschool KW - DNA (Cytosine-5-)-Methyltransferases KW - DNA Methylation KW - Epigenomics KW - Female KW - High-Throughput Nucleotide Sequencing KW - Hirschsprung Disease KW - Humans KW - Male KW - Mice KW - Organogenesis TI - Overexpression of DNMT3b target genes during Enteric Nervous System development contribute to the onset of Hirschsprung disease. TY - research article VL - 7 ER -