RT Journal Article
T1 Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma
A1 Fernandez-Mateos, Javier
A1 Seijas-Tamayo, Raquel
A1 Adansa Klain, Juan Carlos
A1 Pastor Borgonon, Miguel
A1 Perez-Ruiz, Elisabeth
A1 Mesia, Ricard
A1 del Barco, Elvira
A1 Salvador Coloma, Carmen
A1 Rueda Dominguez, Antonio
A1 Caballero Daroqui, Javier
A1 Fernandez Ruiz, Encarnacion
A1 Jesus Cruz-Hernandez, Juan
A1 Gonzalez-Sarmiento, Rogelio
K1 Risk-factors
K1 Molecular-biology
K1 Cancer
K1 Epidemiology
K1 Disease
AB Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma. ATG5 rs2245214 SNP was not associated with any location. Overall, our results indicate the importance of the autophagy pathway in the susceptibility of head and neck squamous cell carcinoma and demonstrate the heterogeneity between its locations encompassed under a single terminology.
PB Nature portfolio
SN 2045-2322
YR 2017
FD 2017-07-31
LK https://hdl.handle.net/10668/26674
UL https://hdl.handle.net/10668/26674
LA en
DS RISalud
RD Apr 17, 2025