RT Journal Article
T1 A Novel Earwax Method to Measure Acute and Chronic Glucose Levels
A1 Herane-Vives, Andrés
A1 Espinoza, Susana
A1 Sandoval, Rodrigo
A1 Ortega, Lorena
A1 Alameda, Luis
A1 Young, Allan H.
A1 Arnone, Danilo
A1 Hayes, Alexander
A1 Benöhr, Jan
K1 Earwax
K1 Glucose
K1 Glycated hemoglobin
K1 Diabetes
K1 Diagnosis
K1 Glucosa
K1 Hemoglobina a glucada
K1 Diabetes mellitus
K1 Diagnóstico
AB Diabetes is the fourth cause of death globally. To date, there is not a practical, as well as an accurate sample for reflecting chronic glucose levels. We measured earwax glucose in 37 controls. Participants provided standard serum, glycated hemoglobin (HbA1c) and earwax samples at two time-points, one month apart. The specimens measured baseline fasting glucose, a follow-up postprandial glucose level and a between sample chronic glucose, calculated using the average level on the two occasions. The baseline earwax sample was obtained using a clinical method and the follow-up using a novel self-sampling earwax device. The earwax analytic time was significantly faster using the novel device, in comparison to the clinical use of the syringe. Earwax accurately reflected glucose at both assessments with stronger correlations than HbA1c. Follow-up postprandial concentrations were more significant than their respective fasting baseline concentrations, reflecting differences in fasting and postprandial glycemia and more efficient standardization at follow up. Earwax demonstrated to be more predictable than HbA1c in reflecting systemic fasting, postprandial and long-term glucose levels, and to be less influenced by confounders. Earwax glucose measurements were approximately 60% more predictable than HbA1c in reflecting glycemia over a month. The self-sampling device provided a sample that might accurately reflect chronic glycemia.
PB MDPI
YR 2020
FD 2020-12-10
LK http://hdl.handle.net/10668/3970
UL http://hdl.handle.net/10668/3970
LA en
NO Herane-Vives A, Espinoza S, Sandoval R, Ortega L, Alameda L, Young AH, et al. Earwax Method to Measure Acute and Chronic Glucose Levels. Diagnostics. 2020 Dec 10;10(12):1069
DS RISalud
RD Apr 7, 2025