%0 Journal Article %A López-Campos, Jose Luis %A Abad Arranz, María %A Calero Acuña, Carmen %A Romero Valero, Fernando %A Ayerbe García, Ruth %A Hidalgo Molina, Antonio %A Aguilar Perez-Grovas, Ricardo I %A García Gil, Francisco %A Casas Maldonado, Francisco %A Caballero Ballesteros, Laura %A Sánchez Palop, María %A Pérez-Tejero, Dolores %A Segado, Alejandro %A Calvo Bonachera, Jose %A Hernández Sierra, Bárbara %A Doménech, Adolfo %A Arroyo Varela, Macarena %A González Vargas, Francisco %A Cruz Rueda, Juan J %T Determinants for changing the treatment of COPD: a regression analysis from a clinical audit. %D 2016 %@ 1176-9106 %U http://hdl.handle.net/10668/2480 %X INTRODUCTIONThis study is an analysis of a pilot COPD clinical audit that evaluated adherence to guidelines for patients with COPD in a stable disease phase during a routine visit in specialized secondary care outpatient clinics in order to identify the variables associated with the decision to step-up or step-down pharmacological treatment.METHODSThis study was a pilot clinical audit performed at hospital outpatient respiratory clinics in the region of Andalusia, Spain (eight provinces with over eight million inhabitants), in which 20% of centers in the area (catchment population 3,143,086 inhabitants) were invited to participate. Treatment changes were evaluated in terms of the number of prescribed medications and were classified as step-up, step-down, or no change. Three backward stepwise binominal multivariate logistic regression analyses were conducted to evaluate variables associated with stepping up, stepping down, and inhaled corticosteroids discontinuation.RESULTSThe present analysis evaluated 565 clinical records (91%) of the complete audit. Of those records, 366 (64.8%) cases saw no change in pharmacological treatment, while 99 patients (17.5%) had an increase in the number of drugs, 55 (9.7%) had a decrease in the number of drugs, and 45 (8.0%) noted a change to other medication for a similar therapeutic scheme. Exacerbations were the main factor in stepping up treatment, as were the symptoms themselves. In contrast, rather than symptoms, doctors used forced expiratory volume in 1 second and previous treatment with long-term antibiotics or inhaled corticosteroids as the key determinants to stepping down treatment.CONCLUSIONThe majority of doctors did not change the prescription. When changes were made, a number of related factors were noted. Future trials must evaluate whether these therapeutic changes impact clinically relevant outcomes at follow-up. %K Quality of care %K Outpatient care %K Treatment strategies %K Follow-up %K Respiratory diseases %K Airway diseases %K Andalucía %K Atención ambulatoria %K Auditoría clínica %K Estudios de seguimiento %K Volumen espiratorio forzado %K Servicio ambulatorio en hospital %K Enfermedad pulmonar obstructiva crónica %K España %K Corticoesteroides %K Antibacterianos %~