%0 Journal Article
%A Garcia Jurado, P. B.
%A Roldan Romero, E.
%A Perez Montilla, M. E.
%A Valverde Moyano, R.
%A Bravo Rey, I. M.
%A Delgado Acosta, F.
%A Bravo-Rodriguez, F. A.
%T Incidens,prognosis, and prediction of haemorrhagic transformation after revascularisation for stroke
%D 2021
%@ 0213-4853
%U https://hdl.handle.net/10668/25374
%X Introduction: Haemorrhagic transformation is a major complication of acute ischaemic stroke (AIS). We sought to determine the predictors and clinical impact of intracranial haemorrhage (ICH) after revascularisation therapy.Methods: We conducted a retrospective, single-centre study including 235 patients with AIS who underwent intravenous recombinant tissue plasminogen activator (IV-rtPA) therapy and/or endovascular treatment. A binary logistic regression model was used to determine the variables associated with ICH, parenchymal haematomas (PH), modified Rankin Scale (mRS) scores, and mortality.Results: ICH was detected in 57 (30 with PH) of 183 patients included. Mechanical thrombectomy, either alone (OR 3.3 [1.42-7.63], P=.005) or in combination with IV-rtPA (OR 3.39 [1,52-7.56], P=.003), was associated with higher risk of ICH, while higher Alberta Stroke Program Early CT scores (OR 0.71 [0.55-0.91], P=.007) were associated with lower risk. Patients with older age (OR 1.07 [1.02-1.13], P=.006) and occlusion of the terminal branch of the internal carotid artery (OR 4.03 [1.35-11.99], P = .012) had a higher risk of PH, while the use of IV-rtPA alone (OR 0.24 [0.08-0.68], P=.008) was associated with lower risk of PH. Only PH was associated with disability as measured by the mRS (OR 3.2 [1.17-8.76], P=.02) and higher mortality (OR 5.06 [1.65-15.5], P=.005).Conclusions: Greater understanding about the predictors of ICH, mRS scores, and mortality could enable better selection of patients and treatments. (C) 2018 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L.U.
%K Intracranial naemorrhage
%K Acute ischaemic stroke
%K Prognosis
%K Haemorrhagic transformation
%K Endovascular treatment
%K Intravenous thrombolysis
%K Acute ischemic-stroke
%K Symptomatic intracranial hemorrhage
%K Mechanical thrombectomy
%K Thrombolysis
%K Guidelines
%K Management
%K Alteplase
%K Score
%K Eso
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