RT Journal Article T1 Unprecedented increase of West Nile virus neuroinvasive disease, Spain, summer 2020. A1 García San Miguel Rodríguez-Alarcón, Lucía A1 Fernández-Martínez, Beatriz A1 Sierra Moros, María José A1 Vázquez, Ana A1 Julián Pachés, Paula A1 García Villacieros, Elena A1 Gómez Martín, María Belén A1 Figuerola Borras, Jordi A1 Lorusso, Nicola A1 Ramos Aceitero, Julian Mauro A1 Moro, Elena A1 de Celis, Aránzazu A1 Oyonarte, Salvador A1 Mahillo, Beatriz A1 Romero González, Luis José A1 Sánchez-Seco, María Paz A1 Suárez Rodríguez, Berta A1 Ameyugo Catalán, Ulises A1 Ruiz Contreras, Santiago A1 Pérez-Olmeda, Mayte A1 Simón Soria, Fernando K1 Spain K1 WNV K1 West Nile fever K1 West Nile virus K1 epidemiology K1 surveillance K1 vector-borne infections K1 viral infections AB Cases of West Nile neuroinvasive disease (WNND) in Spain increased in summer 2020. Here we report on this increase and the local, regional and national public health measures taken in response. We analysed data from regional surveillance networks and the National Epidemiological Surveillance Network, both for human and animal West Nile virus (WNV) infection. During the 2020 season, a total of 77 human cases of WNV infection (median age 65 years; 60% males) were detected in the south-west of Spain; 72 (94%) of these cases developed WNND, presenting as meningoencephalitis, seven of which were fatal. In the previous two decades, only six human cases of WNND were detected in Spain. Reduced activities for vector control this season, together with other factors, might have contributed to the massive increase. Public health measures including vector control, campaigns to raise awareness among physicians and the general population, and interventions to ensure the safety of donations of blood products, organs, cells and tissues were effective to reduce transmission. Going forward, maintenance of vector control activities and an update of the vector-borne diseases response plan in Spain is needed. YR 2021 FD 2021 LK http://hdl.handle.net/10668/17791 UL http://hdl.handle.net/10668/17791 LA en DS RISalud RD Apr 19, 2025