TY - JOUR AU - Aliaga-Gaspar, Pablo AU - Hurtado-Guerrero, Isaac AU - Ciano-Petersen, Nicolas Lundahl AU - Urbaneja, Patricia AU - Brichette-Mieg, Isabel AU - Reyes, Virginia AU - Rodriguez-Bada, Jose Luis AU - Alvarez-Lafuente, Roberto AU - Arroyo, Rafael AU - Quintana, Ester AU - Ramió-Torrentà, Lluis AU - Alonso, Ana AU - Leyva, Laura AU - Fernández, Oscar AU - Oliver-Martos, Begoña PY - 2021 DO - 10.3389/fimmu.2021.778204 UR - https://hdl.handle.net/10668/24479 T2 - Frontiers in immunology AB - Interferon beta receptor 2 subunit (IFNAR2) can be produced as a transmembrane protein, but also as a soluble form (sIFNAR2) generated by alternative splicing or proteolytic cleavage, which has both agonist and antagonist activities for IFN-β.... LA - en KW - IFNAR KW - alternative splicing KW - interferon beta KW - multiple sclerosis KW - soluble receptors KW - Alternative Splicing KW - Biomarkers KW - Drug Monitoring KW - Drug Resistance KW - Female KW - Follow-Up Studies KW - Humans KW - Interferon-beta KW - Male KW - Multiple Sclerosis, Relapsing-Remitting KW - Protein Isoforms KW - RNA, Messenger KW - Receptor, Interferon alpha-beta KW - Treatment Outcome KW - Up-Regulation TI - Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment. TY - research article VL - 12 ER -