RT Journal Article
T1 Epigenetics in Food Allergy and Immunomodulation.
A1 Cañas, José A
A1 Núñez, Rafael
A1 Cruz-Amaya, Anyith
A1 Gómez, Francisca
A1 Torres, María J
A1 Palomares, Francisca
A1 Mayorga, Cristobalina
K1 DNA modification
K1 environmental factors
K1 epigenetic mechanisms
K1 food allergy
AB Food allergy (FA) is an increasing problem worldwide and, over recent years, its prevalence is rising in developed countries. Nowadays, the immunological and cellular processes that occur in the allergic reactions are not fully understood, which hampers the development of in vitro diagnostic tools and further treatment options. Moreover, allergic diseases could be reinforced by environmental exposure and genetic modifications. Gene expression can be controlled by different epigenetic mechanisms like DNA methylation, histone modifications, and microRNAs. In addition, several environmental factors such as dietary components (vitamin D, butyrate, folic acid) are able to regulate this epigenetic mechanism. All these factors produce modifications in immune genes that could alter the development and function of immune cells, and therefore the etiology of the disease. Furthermore, these epigenetic mechanisms have also an influence on immunomodulation, which could explain sustained responsiveness or unresponsiveness during immunotherapy due to epigenetic modifications in key genes that induce tolerance in several FA. Thus, in this review we focus on the different epigenetic mechanisms that occur in FA and on the influence of several dietary components in these gene modifications.
YR 2021
FD 2021-12-01
LK https://hdl.handle.net/10668/24499
UL https://hdl.handle.net/10668/24499
LA en
DS RISalud
RD Apr 12, 2025